Nutritional compositions containing structured fat globules and uses thereof

• US 9,661,874 B2
• Filed: 03/15/2013
• Issued: 05/30/2017
• Est. Priority Date: 03/11/2013
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Banavara, Dattatreya, Gonzalez, Juan, Alvey, John
• Primary Examiner(s): GWARTNEY, ELIZABETH A
• Application Number:
  US13/833,765
• Publication Number:
  US 20140255539A1
• Time in Patent Office: 1,537 Days
• Field of Search: 426 2
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A23V 2250/1588 Copper
• CPC Class Codes: A23V 2250/1592 Iron
• CPC Class Codes: A23V 2250/1598 Iodine
• CPC Class Codes: A23V 2250/16 Potassium
• CPC Class Codes: A23V 2250/161 Magnesium
• CPC Class Codes: A23V 2250/1612 Manganese
• CPC Class Codes: A23V 2250/1614 Sodium
• CPC Class Codes: A23V 2250/1618 Phosphorus
• CPC Class Codes: A23V 2250/1642 Zinc
• CPC Class Codes: A23V 2250/1842 Lecithin
• CPC Class Codes: A23V 2250/1866 Conjugated Linoleic acid
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/1876 Long-chain fatty acids
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/194 Triglycerides
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/304 : Choline
• CPC Class Codes: A23V 2250/54252 : Whey protein
• CPC Class Codes: A23V 2250/612 : Lactose
• CPC Class Codes: A23V 2250/702 : Vitamin A
• CPC Class Codes: A23V 2250/7042 : Vitamin B1
• CPC Class Codes: A23V 2250/7044 : Vitamin B2
• CPC Class Codes: A23V 2250/7046 : Vitamin B3 niacin
• CPC Class Codes: A23V 2250/7052 : Vitamin B6
• CPC Class Codes: A23V 2250/7056 : Vitamin B8 Folic acid
• CPC Class Codes: A23V 2250/706 : Vitamin B12
• CPC Class Codes: A23V 2250/708 : Vitamin C
• CPC Class Codes: A23V 2250/71 : Vitamin D
• CPC Class Codes: A23V 2250/712 : Vitamin E
• CPC Class Codes: A23V 2250/714 : Vitamin K
• CPC Class Codes: A23V 2250/72 : Biotin

Abstract

The present disclosure relates to a lipid source for nutritional compositions, comprising an enriched lipid fraction which comprises structured fat globules. The enriched lipid fraction provides fat globules having a desired size and fatty acid composition and may be stabilized by components such as phospholipids, cholesterol, milk-fat globule membrane protein and combinations thereof. Additionally, the disclosure relates to methods of supporting lipid digestion in a pediatric subject by providing a nutritional composition comprising an enriched lipid fraction having structured fat globules that are more accessible to lipases. The chemical composition, size and structure of the fat globules may improve digestion. The disclosed nutritional compositions may provide additive and or/synergistic beneficial health effects.

Claims

1. A powdered a nutritional composition comprising:

a carbohydrate source;

a lipid or fat source, wherein the lipid or fat source comprises milk fat globules formed from an enriched lipid fraction derived from bovine milk that has been subjected to a fractionation procedure, further wherein the milk fat globules comprise based on the total weight of the lipids present in the milk fat globules 49.2 wt % saturated fatty acids, 40.7 wt % mono-unsaturated fatty acids, and 4.4 wt % poly-unsaturated fatty acids;

a protein source; and

a preservative.

2. The composition of claim 1, wherein the milk fat globules comprise based on the total weight of fatty acids present in the milk fat globules 5 wt % trans fatty acids.

3. The composition of claim 1, wherein the milk fat globules comprise based on the total weight of fatty acids present in the milk fat globules 0.8 wt % conjugated linoleic acid.

4. The composition of claim 1, wherein the milk fat globules comprise based on the total weight of fatty acids present in the milk fat globules 0.4 wt. % cholesterol.

5. The composition of claim 1, wherein the milk fat globules comprise based on the total weight of fatty acids present in the milk fat globules 0.2 wt. % phospholipids.

6. The composition of claim 1, wherein the average diameter of the milk fat globules is at least about 2 μ

m.

7. The composition of claim 1, wherein the average diameter of the milk fat globules range is in the range of about 2 μ

m to about 13 μ

m.

8. The composition of claim 1, wherein the average diameter of the milk fat globules range is in the range of about 3 μ

m to about 6 μ

m.

9. The composition of claim 1, wherein the specific surface area of the milk fat globules range is in the range of about 0.9 m²/g to about 3 m²/g.

10. The composition of claim 1, further comprising docosahexaenoic acid.

11. The composition of claim 1, further comprising at least one prebiotic.

12. The composition of claim 11, wherein the at least one prebiotic is selected from the group consisting of polydextrose, galactooligosaccharides, and combinations thereof.

13. The composition of claim 12, wherein polydextrose and galactooligosaccharides are added to the nutritional composition in an amount of at least about 0.2 mg/100 kcal to about 1.5 mg/100 kcal.

14. The composition of claim 1, further comprising β

-glucan.

15. The composition of claim 1, further comprising a source of iron.

16. The composition of claim 1, wherein the fractionation procedure is melt fractionation.

20. The composition of claim 1, wherein the milk fat globules further comprise 5 wt. % trans fatty acids;

0.8 wt. % conjugated linoleic acid;

0.4 wt % cholesterol; and

0.2 wt % phospholipids.

17. A powdered nutritional composition comprising:

a carbohydrate source;

a lipid or fat source, wherein the lipid or fat source comprises milk fat globules formed from an enriched lipid fraction derived from bovine milk that has been subjected to a fractionation procedure, further wherein the milk fat globules comprise based on the total weight of the lipids present in the milk fat globules 50.7 wt. % saturated fatty acids, 35.4 wt. % mono-unsaturated fatty acids, 4.4% poly-unsaturated fatty acids, and 4.3 wt % trans fatty acids;

a protein source; and

a preservative.

18. The nutritional composition of claim 17, wherein the milk fat globules further comprise 0.8 wt % conjugated linoleic acid.

19. The composition of claim 17, wherein the fractionation procedure is supercritical fluid fractionation.