Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film

• US 9,662,008 B2
• Filed: 05/02/2016
• Issued: 05/30/2017
• Est. Priority Date: 04/01/2009
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Korb, Donald R., Weber, William L., Chinnock, Randal B., Gravely, Benjamin T., Grenon, Stephen M.
• Primary Examiner(s): PINKNEY, DAWAYNE
• Application Number:
  US15/143,834
• Publication Number:
  US 20160242640A1
• Time in Patent Office: 393 Days
• Field of Search: 351206, 351200, 351205, 351209-210, 351221-223, 351245-246, 351212, 351208, 351160 R, 351159, 351247
• CPC Class Codes: A61B 3/0025 characterised by electronic signal processing, e.g. eye models
• CPC Class Codes: A61B 3/0041 characterised by display arrangements
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: G06T 2207/30041 Eye; Retina; Ophthalmic
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

Claims

1. A method of measuring a tear film layer thickness (TFLT) of an ocular tear film, comprising:

(a) receiving at least one first image containing optical wave interference of specularly reflected light and a background signal from a region of interest of an ocular tear film while illuminated by a multi-wavelength light source;

(b) detecting whether an eyelid blink was captured in the at least one first image;

(c) removing any images in the at least one first image on which the eyelid blink was detected to produce at least one resulting image;

(d) converting at least a portion of the at least one resulting image representing the optical wave interference of specularly reflected light from at least a portion of the region of interest of the ocular tear film into at least one color-based value;

(e) comparing the at least one color-based value to a tear film layer optical wave interference model; and

(f) measuring a TFLT of the at least a portion of the region of interest of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model.

2. The method of claim 1, further comprising detecting whether a partial eyelid blink was captured in the at least one first image.

3. The method of claim 1, further comprising detecting whether a full eyelid blink was captured in the at least one first image.

4. The method of claim 1, further comprising:

(g) receiving at least one second image containing a background signal from the region of interest of the ocular tear film; and

(h) subtracting the at least one second image from the at least one first image to generate the at least one resulting image containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced.

5. The method of claim 4, further comprising:

detecting whether an eyelid blink was captured in the at least one second image; and

removing any images in the at least one second image on which the eyelid blink was detected.

6. The method of claim 4, further comprising:

capturing the optical wave interference of specularly reflected light and the background signal from the region of interest of the ocular tear film while illuminated by the multi-wavelength light source in the at least one first image; and

capturing the background signal from the region of interest of the ocular tear film in the at least one second image.

7. The method of claim 1, wherein the tear film layer optical wave interference model is comprised of a theoretical tear film layer optical wave interference model.

8. The method of claim 1, further comprising applying a threshold function to the at least one resulting image.

9. The method of claim 1, further comprising applying at least one of a spatial erode function and a dilate function to the at least one resulting image.

10. The method of claim 4, further comprising sequentially repeating step (a) to receive a plurality of first images and step (g) to receive a plurality of second images interleaved with the plurality of first images to provide a plurality of first and second image pairs.

11. The method of claim 10, comprising subtracting the plurality of second images from the plurality of first and second image pairs from the corresponding plurality of first images from the plurality of first and second image pairs to generate a plurality of resulting images each containing the optical wave interference of specularly reflected light from the region of interest of the ocular tear film with the background signal removed or reduced.

12. The method of claim 1, comprising detecting whether the eyelid blink was captured in the at least one first image based on a function of an intensity of the at least one resulting image.

13. The method of claim 1, comprising detecting whether the eyelid blink was captured in the at least one first image by detecting a pupil in the at least one first image.

14. The method of claim 1, further comprising adjusting the at least one color-based value in the at least one resulting image based on the International Colour Consortium (ICC).

15. The method of claim 1, further comprising subtracting an offset from the at least one resulting image.

16. The method of claim 1, wherein the at least one color-based value is comprised of at least one red-green-blue (RGB) component value.

17. The method of claim 1, comprising comparing the at least one color-based value to the tear film layer optical wave interference model by determining a closest matching entry in the tear film layer optical wave interference model to the at least one color-based value.

18. The method of claim 17, comprising determining the closest matching entry by determining a closest distance between the at least one color-based value to a color-based value in the tear film layer optical wave interference model.

19. The method of claim 1, comprising measuring the TFLT of the at least a portion of the region of interest of the ocular tear film based on the comparison of the at least one color-based value to the tear film layer optical wave interference model by measuring at least one of a lipid layer thickness (LLT) and an aqueous layer thickness (ALT).

20. The method of claim 1, wherein the tear film layer optical wave interference model is comprised of a plurality of color-based values each corresponding to at least one of a lipid layer thickness (LLT) and an aqueous layer thickness (ALT).

21. The method of claim 1, wherein the tear film layer optical wave interference model is limited to a plurality of color-based values that do not exceed a representation of 240 nanometers (nm) of lipid layer thickness (LLT).

22. The method of claim 1, wherein the tear film layer optical wave interference model is comprised of at least two dimensions comprised of a first dimension containing a plurality of color-based values each corresponding to a lipid layer thickness (LLT), and a second dimension containing a plurality of color-based values each corresponding to an aqueous layer thickness (ALT).

23. The method of claim 1, wherein the tear film layer optical wave interference model is a model comprised from the group consisting of a 2-wave tear film layer optical wave interference model and a 3-wave tear film layer optical wave interference model.

24. The method of claim 1, wherein the at least a portion of the at least one resulting image representing the optical wave interference of specularly reflected light from the at least a portion of the region of interest of the ocular tear film represents a pixel in the at least one resulting image.

25. The method of claim 1, wherein the at least one color-based value is comprised of a plurality of color-based values representing the optical wave interference of specularly reflected light from a plurality of portions of the region of interest of the ocular tear film.

26. The method of claim 25, comprising:

comparing each of the plurality of color-based values to the tear film layer optical wave interference model; and

measuring the TFLT for each of the plurality of color-based values based on the comparison of each of the plurality of color-based values to the tear film layer optical wave interference model.

27. The method of claim 26, further comprising averaging the comparison of each of the plurality of color-based values to the tear film layer optical wave interference model.

28. The method of claim 26, further comprising measuring the TFLT by determining closest matching entries between each of the plurality of color-based values to color-based values in the tear film layer optical wave interference model.

29. The method of claim 1, further comprising the multi-wavelength light source configured to illuminate the region of interest of the ocular tear film with multi-wavelength light.

30. The method of claim 29, wherein the multi-wavelength light source is comprised of a multi-wavelength Lambertian light source configured to uniformly or substantially uniformly illuminate the region of interest of the ocular tear film.