Analyte sensors having temperature independent membranes

• US 9,662,055 B2
• Filed: 07/13/2015
• Issued: 05/30/2017
• Est. Priority Date: 07/28/2010
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hoss, Udo, Feldman, Benjamin J., Ouyang, Tianmei
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): MESSERSMITH, ERIC J
• Application Number:
  US14/798,047
• Publication Number:
  US 20150313520A1
• Time in Patent Office: 687 Days
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: C12Q 1/002 Electrode membranes

Abstract

Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Claims

1. A membrane structure, comprising:

a first membrane having a negative temperature coefficient; and

a second membrane having a positive temperature coefficient;

wherein the first membrane is covalently bonded to the second membrane to form a stacked membrane structure that has an analyte permeability that is substantially temperature independent.

2. The membrane structure of claim 1, wherein the membrane structure is temperature independent over a range of temperatures.

3. The membrane structure of claim 2, wherein the range of temperatures is from 25°

C. to 45°

C.

4. The membrane structure of claim 1, wherein the membrane structure is configured to have a total temperature coefficient that is substantially zero.

5. The membrane structure of claim 1, wherein the first membrane is configured to have an analyte permeability that varies inversely with temperature, and the second membrane is configured to have an analyte permeability that varies directly with temperature.

6. The membrane structure of claim 1, wherein the first membrane comprises:

poly(styrene-co-maleic anhydride), dodecylamine and polypropylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) (2-aminopropyl ether) crosslinked with poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol) bis(2-aminopropyl ether);

poly(n-isopropyl acrylamide);

or a copolymer of poly(ethylene oxide) and poly(propylene oxide).

7. The membrane structure of claim 1, wherein the second membrane comprises polyvinylpyridine, a derivative of polyvinylpyridine, polyvinylimidazole, a derivative of polyvinylimidazole, or a combination thereof.

8. The membrane structure of claim 1, wherein the membrane structure further comprises a third membrane comprising a polymer and an analyte responsive enzyme.

9. The membrane structure of claim 1, wherein the membrane structure is chemically bound to the third membrane.

10. The membrane structure of claim 1, wherein the first or second membrane is laminated to the third membrane.

11. The membrane structure of claim 1, wherein the first or second membrane is crosslinked to the third membrane.

12. The membrane structure of claim 1, wherein the membrane structure is configured to be a diffusion-limiting membrane structure.

13. The membrane structure of claim 1, wherein the membrane structure is configured to be a size-exclusion membrane structure.

14. The membrane structure of claim 1, wherein the third membrane further comprises a redox mediator.

15. The membrane structure of claim 14, wherein at least one of the analyte-responsive enzyme and the redox mediator is chemically bound to the polymer.

16. The membrane structure of claim 14, wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.

17. The membrane structure of claim 1, wherein the first membrane comprises poly(n-isopropyl acrylamide).

18. The membrane structure of claim 1, wherein the first membrane comprises a copolymer of poly(ethylene oxide) and poly(propylene oxide).

19. The membrane structure of claim 1, wherein the second membrane comprises polyvinylpyridine.

20. The membrane structure of claim 1, wherein the second membrane comprises polyvinylimidazole.