Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy

• US 9,662,069 B2
• Filed: 10/27/2015
• Issued: 05/30/2017
• Est. Priority Date: 10/07/2008
• Status: Active Grant

• Current Assignee: Medidata Solutions Incorporated (Dassault Systemes SA)
• Original Assignee: MC10, Inc.
• Inventors: De Graff, Bassel, Ghaffari, Roozbeh, Arora, William J.
• Primary Examiner(s): Lee, Calvin
• Application Number:
  US14/924,400
• Publication Number:
  US 20160045162A1
• Time in Patent Office: 581 Days
• Field of Search: 257291, 257773-786, 438455-457, 607115
• CPC Class Codes: A61B 1/05 characterised by the image sensor, e.g. camera, being in the distal end portion
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00339 Spine, e.g. intervertebral disc
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 2562/166 the sensor is mounted on a specially adapted printed circuit board
• CPC Class Codes: A61B 5/0024 for multiple sensor units attached to the patient, e.g. using a body or personal area network
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/259 using conductive adhesive means, e.g. gels
• CPC Class Codes: A61B 5/28 for electrocardiography [ECG]
• CPC Class Codes: A61B 5/6821 : Eye
• CPC Class Codes: A61B 5/6833 : Adhesive patches
• CPC Class Codes: A61B 5/6847 : mounted on an invasive device
• CPC Class Codes: A61B 5/6869 : Heart
• CPC Class Codes: A61B 8/12 : in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61N 7/022 : intracavitary
• CPC Class Codes: H01L 27/14618 : Containers
• CPC Class Codes: H01L 27/14632 : Wafer-level processed structures
• CPC Class Codes: H01L 27/14645 : Colour imagers
• CPC Class Codes: H01L 27/14687 : Wafer level processing
• CPC Class Codes: H01L 27/14692 : Thin film technologies, e.g. amorphous, poly, micro- or nanocrystalline silicon
• CPC Class Codes: H01L 2924/00 : Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 : Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
• CPC Class Codes: H01L 2924/1433 : Application-specific integrated circuit [ASIC]
• CPC Class Codes: H01L 2924/19041 : being a capacitor
• CPC Class Codes: H01L 2924/19042 : being an inductor
• CPC Class Codes: H01L 2924/19043 : being a resistor
• CPC Class Codes: H01L 2924/30105 : Capacitance

Abstract

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.

Claims

1. A conformal sensor tape for monitoring vital signs, the tape comprising:

a conformal substrate;

an integrated circuit mounted on the conformal substrate;

an inductive transmitter coil mounted on the conformal substrate and coupled to the integrated circuit;

a positive electrode coupled to the integrated circuit; and

a negative electrode coupled to the integrated circuit;

wherein electrical signals received by the positive electrode and the negative electrode are transferred to the integrated circuit, and the integrated circuit induces an RF signal in the inductive transmitter coil.

2. The conformal sensor tape of claim 1, further comprising an amplifier connecting at least one of the positive electrode and the negative electrode to the integrated circuit.

3. The conformal sensor tape of claim 1, further comprising a ground electrode coupled to the integrated circuit.

4. The conformal sensor tape of claim 1, wherein the conformal substrate has a perimeter portion and a central portion, and the positive electrode and the negative electrode are located in the central portion of the conformal substrate, and wherein the inductive transmitter coil extends along the perimeter portion around the positive electrode and the negative electrode.

5. The conformal sensor tape of claim 1, wherein the positive electrode and the negative electrode are ECG electrodes.

6. The conformal sensor tape of claim 1, wherein the tape has a thickness of 300 to 500 μ

m.

7. The conformal sensor tape of claim 1, further comprising one or more passive filters coupled to the integrated circuit and configured to optimize signal to noise ratio.

8. The conformal sensor tape of claim 1, further comprising a capacitor coupled to at least one of the inductive transmitter coil and the integrated circuit.

9. The conformal sensor tape of claim 1, wherein the conformal substrate is formed of (poly)dimethylsiloxane (PDMS).

10. The conformal sensor tape of claim 1, wherein the vital signs relate to one or more of surface topology, temperature, pressure, electrical conductivity, pH, chemical, and enzymatic activity of a user upon which the tape is placed.

11. The conformal sensor tape of claim 1, wherein the inductive transmitter coil, the positive electrode, and the negative electrode are coupled to the integrated circuit via stretchable electrical interconnects.

12. The conformal sensor tape of claim 1, wherein the integrated circuit is flexible.

13. The conformal sensor tape of claim 1, wherein the conformal substrate has a perimeter portion, and the inductive transmitter coil extends along at least a portion of the perimeter portion.

14. The conformal sensor tape of claim 13, wherein the inductive transmitter coil extends along an entirety of the perimeter portion.

15. The conformal sensor tape of claim 1, further comprising a power source coupled to the integrated circuit.

16. The conformal sensor tape of claim 15, wherein the power source is a battery.

17. The conformal sensor tape of claim 1, further comprising an inductive receiver coil coupled to the integrated circuit.

18. The conformal sensor tape of claim 17, wherein the conformal substrate has a perimeter portion and a central portion, the inductive transmitter coil extends along at least a portion of the perimeter portion, and the inductive receiver coil is located in the central portion.

19. The conformal sensor tape of claim 17, wherein the inductive receiver coil contains 19.5 turns and has an inductance of 20 μ

H.

20. The conformal sensor tape of claim 19, wherein the inductive transmitter coil contains 16 turns and has an inductance of 220 μ

H.