Implantable medical devices having controlled surface properties for improved healing response

• US 9,662,230 B2
• Filed: 06/24/2011
• Issued: 05/30/2017
• Est. Priority Date: 11/19/1999
• Status: Expired due to Term

• Current Assignee: Vactronix Scientific, LLC
• Original Assignee: Vactronix Scientific, Inc.
• Inventors: Palmaz, Julio C., Sprague, Eugene A.
• Primary Examiner(s): Sharma, Yashita
• Assistant Examiner(s): PRESTON, REBECCA STRASZHEIM
• Application Number:
  US13/168,844
• Publication Number:
  US 20120136427A1
• Time in Patent Office: 2,167 Days
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2220/0041 using additional screws, bolts, dowels or rivets, e.g. connecting screws
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61L 27/04 Metals or alloys
• CPC Class Codes: A61L 27/3679 Hollow organs, e.g. bladder, esophagus, urether, uterus, intestine
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: Y10T 29/49936 Surface interlocking

Abstract

An implantable medical device that is fabricated from materials that present a blood or body fluid or tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a monolithic material formed into differentiated regions defining structural members and web regions extending across interstitial spaces between the structural members. The endoluminal stent-graft is characterized by having controlled heterogeneities at a the blood flow surface of the stent.

Claims

1. An implantable medical device comprising:

a vacuum deposited biomaterial, the implantable medical device having a substantially tubular configuration with a luminal surface thereof, the luminal surface having a non-random distribution of cell attachment sites or binding domains thereupon, the distribution being substantially homogenous about the luminal surface, the cell attachment cites or binding domains further including oxidation and organic adsorption patterns.

2. The implantable medical device according to claim 1, wherein the vacuum deposited biomaterial is selected from the group consisting of elemental titanium, vanadium, aluminum, nickel, tantalum, zirconium, chromium, silver, gold, silicon, magnesium, niobium, scandium, platinum, cobalt, palladium, manganese, molybdenum and alloys thereof, nitinol, and stainless steel.

3. The implantable medical device according to claim 2, wherein each binding domain is dimensioned to have a blood contact surface area substantially similar in size as endothelial cell surface integrin clusters.

4. The implantable medical device according to claim 3, wherein the binding domains have an inter-binding spacing of less than a nominal diameter of a human endothelial cell.

5. The implantable medical device according to claim 4, wherein the blood contact surface area is less than about 6 μ

m².

6. The implantable medical device according to claim 4, wherein each blood contact surface area has a blood contact surface less than or equal, to about 10 μ

m and a border-to-border spacing between binding domains is about 2 μ

m.