Side effect ameliorating combination therapeutic products and systems

• US 9,662,391 B2
• Filed: 06/05/2008
• Issued: 05/30/2017
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Harvest Bio LLC
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Levien, Royce A., Leuthardt, Eric C., Lord, Robert W., Sweeney, Elizabeth A., Wood, Jr., Lowell L., Malamud, Mark A., Wood, Victoria Y. H.
• Primary Examiner(s): NGUYEN, HIEP VAN
• Application Number:
  US12/156,949
• Publication Number:
  US 20090271217A1
• Time in Patent Office: 3,281 Days
• Field of Search: 705 2
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/5415 ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

Combination therapeutics, computer program products, and systems are described that include at least one combined prescription psychiatric medication and at least one artificial sensory experience for ameliorating at least one side effect of the psychiatric medication.

Claims

1. A computer process for controlling a system including at least one or more codes that are associated with at least one dosage of at least one medication for treating schizophrenia and that are usable to gain electronic access to at least one secured application for treating schizophrenia, and a smartphone device including at least one or more wireless communication units, at least one user interface, and at least one computer processor, the computer process including operations comprising:

accessing, at least partly via the one or more wireless communication units of the smartphone device using the one or more codes, the at least one secured application for treating schizophrenia in combination with use of the at least one medication;

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of schizophrenia associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of the at least one secured application for treating schizophrenia including at least;

providing at least some interactive digital content requesting input from the individual to achieve an objective;

obtaining input from the individual with respect to the objective; and

measuring a level of success with respect to achieving the objective based at least partly on obtained input of the individual.

2. A computer process for controlling a smartphone device including at least one or more wireless communication units, at least one user interface, one or more computer readable media, and at least one computer processor, the computer process including operations comprising:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least;

providing at least some interactive digital content requesting input from the individual to achieve an objective;

obtaining input from the individual with respect to the objective; and

measuring a level of success with respect to achieving the objective based at least partly on obtained input of the individual.

3. The computer process of claim 2, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia comprises:

accepting, at least partly via the at least one touchscreen, graphical user interface, or tactile interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia.

4. The computer process of claim 2, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia comprises:

accepting, at least partly via the at least one user interface of the smartphone device and one or more instruments for detecting and/or measuring, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia.

5. The computer process of claim 2, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia comprises:

accepting, at least partly as user input provided via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia.

6. The computer process of claim 2, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one medication for treating schizophrenia;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking.

7. The computer process of claim 2, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom, side effect, adverse effect, response, or reaction associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual.

8. The computer process of claim 2, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one physical symptom, mental symptom, or mental impairment associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual.

9. The computer process of claim 2, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect comprises:

presenting, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect.

10. The computer process of claim 2, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect comprises:

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect at one or more staggered times relative to use of the at least one medication for treating schizophrenia.

11. The computer process of claim 2, wherein the providing at least some interactive digital content requesting input from the individual to achieve an objective comprises:

providing at least one of the following types of interactive digital content;

online educational experience, virtual world, virtual reality, social networking interface, online game, networked game, single player game, simulated reality, or virtual tour.

12. The computer process of claim 2, wherein the providing at least some interactive digital content requesting input from the individual to achieve an objective comprises:

providing at least some interactive digital content requesting input from the individual to achieve an objective with respect to at least one cognitive capability.

13. The computer process of claim 2, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating schizophrenia comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one medication for treating schizophrenia;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking,

wherein identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual includes, but is not limited to, identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of schizophrenia associated with the individual based at least partly on at least one of the one or more of the following indications of the individual;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking, and

wherein the providing at least some interactive digital content requesting input from the individual to achieve an objective includes, but is not limited to, providing at least some interactive digital content to tutor the individual with respect to the at least one of the one or more of the following indications;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking.

14. A computer process for controlling a smartphone device including at least one or more wireless communication units, at least one user interface, one or more computer readable media, and at least one computer processor, the computer process including operations comprising:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect.

15. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one touchscreen, graphical user interface, or tactile interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition.

16. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device and one or more instruments for detecting and/or measuring, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition.

17. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly as user input provided via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition.

18. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more of the following types of mental attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

anxiety, psychosis, depression, fear, inattention, mood change, phobia, eating issue, development issue, communication issue, socialization issue, personality change, irrational or disturbed thinking, hallucination, delusional belief, or disorganized thinking.

19. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more of the following types of physical attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

pain, hypertension, sweating, dizziness, lightheadedness, abnormal respiration, headache, fatigue, nausea, fever, abnormal heart rhythm, motor weakness, abnormal heart rate, appearance, or behavior.

20. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more measurements of one or more of the following attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

physiological brain activity, cardiac activity, vascular activity, peripheral neural signal, hemodynamic activity, or metabolic activity.

21. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more of the following types of medical history attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

illness, symptom, medicine, treatment, health risk factor, relation of individual, life history, or drug use.

22. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking.

23. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one of the following types of medications;

mood stabilizer, antidepressant, stimulant, anxiolytic, or hypnotic.

24. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken an antipsychotic.

25. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom, side effect, adverse effect, response, or reaction associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual.

26. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one physical symptom, mental symptom, or mental impairment associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual.

27. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

selecting, at least partly using the at least one computer processor of the smartphone device, at least one application based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of the at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect.

28. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

presenting, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect.

29. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect at one or more staggered times relative to administration of the at least one medication, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect.

30. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least one online educational experience, virtual world, virtual reality, social networking interface, online game, networked game, single player game, simulated reality, or virtual tour to achieve at least one objective with respect to the at least one effect.

31. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to at least one cognitive capability.

32. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one antipsychotic medication;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking,

wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual includes, but is not limited to, identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of schizophrenia associated with the individual based at least partly on at least one of the one or more of the following indications of the individual;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking, and

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one interactive digital therapy application to tutor the individual with respect to the at least one of the one or more of the following indications;

mood change, impairment of perception or expression of reality, auditory hallucination, paranoid or bizarre delusion, disorganized speech, or disorganized thinking.

33. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one anxiolytic medication;

subjective indication of anxiety, sweating, abnormal respiration, abnormal heart rhythm, abnormal heart rate, appearance, or behavior,

wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual includes, but is not limited to, identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of anxiety associated with the individual based at least partly on at least one of the one or more of the following indications of the individual;

subjective indication of anxiety, sweating, abnormal respiration, abnormal heart rhythm, abnormal heart rate, appearance, or behavior, and

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one interactive digital therapy application to treat anxiety.

34. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one anti-anxiety medication;

subjective indication of anxiety, sweating, abnormal respiration, abnormal heart rhythm, abnormal heart rate, appearance, or behavior,

wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual includes, but is not limited to, identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of stress associated with the individual based at least partly on at least one of the one or more of the following indications of the individual;

subjective indication of anxiety, sweating, abnormal respiration, abnormal heart rhythm, abnormal heart rate, appearance, or behavior, and

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one digital deep breathing assistant to provide relaxation therapy to the individual.

35. The computer process of claim 14, wherein the accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental disorder or condition comprises:

accepting, at least partly via the at least one user interface of the smartphone device, one or more of the following indications of an individual who is taking or has taken at least one anti-depressant medication;

subjective input of mood, location, appearance, or behavior,

wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual includes, but is not limited to, identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of depression associated with the individual based at least partly on at least one of the one or more of the following indications of the individual;

subjective input of mood, location, appearance, or behavior, and

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one user interface modification to at least one social networking website improve mood of the individual.

36. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one mood change associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one user interface modification to at least one application to address the mood change of the individual.

37. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one addiction symptom associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least some interactive digital therapy to treat addiction.

38. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one addiction withdrawal symptom associated with the individual based at least partly on the one or more indications of restlessness or agitation,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least some audio therapy to treat addiction withdrawal.

39. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one cognition issue associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one game to facilitate exercise of mental faculties of the individual.

40. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one attention deficit associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one game that requires mental concentration to achieve one or more goals.

41. The computer process of claim 14, wherein the identifying, at least partly using the at least one computer processor of the smartphone device, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual comprises:

identifying, at least partly using the at least one computer processor of the smartphone device, at least one indication of at least one pain associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual,

wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect includes, but is not limited to, implementing, at least partly via the at least one user interface of the smartphone device, at least one game to distract the individual.

42. The computer process of claim 14, further comprising:

controlling at least one administration unit to administer the at least one medication for treating at least one mental disorder or condition.

43. The computer process of claim 14, further comprising:

transmitting at least one indication regarding implementation of the at least some interactive digital content to at least one remote healthcare provider system for access by at least one healthcare provider.

44. The computer process of claim 14, wherein the implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one application for addressing the at least one effect, including at least providing at least some interactive digital content to achieve at least one objective with respect to the at least one effect comprises:

providing at least one user interface enabling interaction with at least one professional person for addressing the at least one effect.

45. A mobile computing device comprising:

at least one user interface;

at least one computer processor; and

one or more computer readable media bearing one or more instructions that, when executed, program the at least one computer processor to perform operations including at least;

accepting, at least partly via the at least one user interface, one or more indications of one or more attributes of an individual who is taking or has taken at least one medication for treating at least one mental condition;

identifying, at least partly using the at least one computer processor, at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface, at least one aspect of at least one application for addressing the at least one effect, including at least;

providing at least some interactive digital content requesting input from the individual to achieve an objective;

obtaining input from the individual with respect to the objective; and

measuring a level of success with respect to achieving the objective based at least partly on obtained input of the individual.

46. A combination therapeutic comprising:

at least one consumer package containing at least;

at least one medication for treating at least one mental condition; and

one or more codes for accessing or one or more computer readable media bearing one or more instructions that, when executed, program at least one computer processor to perform operations including at least;

accepting one or more indications of one or more attributes of an individual who is taking or has taken the at least one medication for treating at least one mental condition;

identifying at least one effect associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing at least one aspect of at least one application for addressing the at least one effect, including at least;

providing at least some interactive digital content requesting input from the individual to achieve an objective;

obtaining input from the individual with respect to the objective; and

measuring a level of success with respect to achieving the objective based at least partly on obtained input of the individual.

47. A computer process for controlling a smartphone device including at least one or more wireless communication units, at least one user interface, one or more computer readable media, and at least one computer processor, the computer process including operations comprising:

accepting, at least partly via the at least one user interface of the smartphone device, one or more indications of one or more of the following attributes of an individual who is taking or has taken at least one medication for treating depression;

sleep, activity, energy, despair, despondence, sense of inadequacy, mood, social network application usage history, location, appearance, or behavior;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of depression associated with the individual based at least partly on the one or more indications of the one or more attributes of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one software application to achieve at least one improvement in the at least one symptom of depression.

48. A computer process for controlling a smartphone device including at least one or more wireless communication units, at least one user interface, one or more computer readable media, and at least one computer processor, the computer process including operations comprising:

accepting, at least partly via the at least one user interface of the smartphone device, one or more measurements of pain of an individual who is taking or has taken at least one medication for treating pain;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of pain associated with the individual based at least partly on the one or more measurements of pain of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one software application to achieve at least one improvement in the at least one symptom of pain associated with the individual.

49. A computer process for controlling a smartphone device including at least one or more wireless communication units, at least one user interface, one or more computer readable media, and at least one computer processor, the computer process including operations comprising:

accepting, at least partly via the at least one user interface of the smartphone device, one or more measurements of mental functioning of an individual who is taking or has taken at least one medication for treating a condition related to cognition;

identifying, at least partly using the at least one computer processor of the smartphone device, at least one symptom of the condition related to cognition associated with the individual based at least partly on the one or more measurements of mental functioning of the individual; and

implementing, at least partly via the at least one user interface of the smartphone device, at least one aspect of at least one software application to achieve at least one improvement in the condition related to cognition associated with the individual.

50. The computer process of claim 49, wherein the condition related to cognition comprises:

multiple sclerosis.

51. The computer process of claim 49, wherein the condition related to cognition comprises:

neurodegeneration.

52. The computer process of claim 49, wherein the condition related to cognition comprises:

schizophrenia.

53. The computer process of claim 49, wherein the condition related to cognition comprises:

attention-deficit hyperactivity disorder.