Probe, especially a probe for neural applications

• US 9,662,494 B2
• Filed: 10/16/2013
• Issued: 05/30/2017
• Est. Priority Date: 10/16/2012
• Status: Active Grant

• Current Assignee: Medtronic Bakken Research Center B.V. (Medtronic Plc)
• Original Assignee: Medtronic Bakken Research Center B.V. (Medtronic Plc)
• Inventors: Young, Edward Willem Albert
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US14/436,397
• Publication Number:
  US 20150265835A1
• Time in Patent Office: 1,322 Days
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 2562/222 Electrical cables or leads therefor, e.g. coaxial cables or ribbon cables
• CPC Class Codes: A61B 2562/227 Sensors with electrical connectors
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/293 Invasive
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/3754 Feedthroughs
• CPC Class Codes: Y10T 29/49169 Assembling electrical component directly to terminal or elongated conductor

Abstract

The present invention relates to a probe comprising at least one lead and an Advanced Lead Connector (ALC) element, the lead comprising at least one thin film, whereby the thin film comprises a proximal end and a distal end, the lead further comprising a plurality of electrodes on the distal end of the thin film, the ALC element comprising electronic means to address the plurality of electrodes and at least one ALC connecting means, whereby the proximal end of the thin film and the ALC connecting means are connected by an interposing means so as to form at least an electric and/or electronic connection between the electrodes and the ALC element. Furthermore, the present invention relates to a neurostimulation and/or neurorecording system, an interposing means, an assembly comprising at least one thin film for a lead of a probe and an ALC element and a method of manufacturing a probe.

Claims

1. A system for at least one of neurostimulation or neurorecording, the system comprising a probe comprising:

at least one lead comprising at least one thin film, wherein the thin film comprises a proximal end and a distal end, the lead further comprising a plurality of electrodes on the distal end of the thin film; and

an Advanced Lead Connector (ALC) element comprising means for electronically addressing the plurality of electrodes, a feed-through element, and a plurality of feed-through pins through the feed-through element for connecting the ALC element with the proximal end of the at least one thin film,

wherein the proximal end of the thin film and the plurality of feed-through pins through the feed-through element are connected by an interposing element at least partially between the proximal end of the thin film and the plurality of feed-through pins so as to form at least one of an electric or electronic connection between the plurality of electrodes and the ALC element, a first plurality of connections between the proximal end of the thin film and the interposing element defining a first footprint smaller than a second footprint defined by a second plurality of connections between the interposing element and the plurality of feed-through pins through the feed-through element, and wherein the first plurality of connections and the second plurality of connections are disposed at least partially through the interposing element.

2. The system according to claim 1,

wherein the interposing element comprises a flexible foil with at least one metal track.

3. The system according to claim 2,

wherein the interposing element comprises a flexible printed circuit board (PCB).

4. The system according to claim 1,

wherein the interposing element comprises one or more of a parylene carrier, a polyimide carrier, a liquid crystal polymer carrier, or one or more gold tracks.

5. The system according to claim 1,

wherein one or more of the first plurality of connections between the proximal end of the thin film and the interposing element or the second plurality of connections between the interposing element and the plurality of feed-through pins is at least partially formed by one or more of wire bonding, rivet gold bonding, or stud bump bonding.

6. The system according to claim 1,

wherein one or more of the first plurality of connections between the proximal end of the thin film and the interposing element or the second plurality of connections between the interposing element and the plurality of feed-through pins is at least partially formed by one or more of soldering or laser welding.

7. The system according to claim 1,

wherein one or more of the first plurality of connections between the proximal end of the thin film and the interposing element or the second plurality of connections between the interposing element and the plurality of feed-through pins is at least partially formed by a conductive glue.

8. The system according to claim 1,

wherein the feed-through element comprises a ceramic feed-through element with the plurality of feed-through pins, the plurality of feed-through pins electrically coupled to a respective connection of the second plurality of connections.

9. The system according to claim 1,

wherein the interposing element has a thickness greater than the thin film.

10. The system of claim 1, wherein the system is configured to deliver deep brain stimulation (DBS) via the probe.

11. The system of claim 1, further comprising a controller configured to supply electrical stimulation pulses to the ALC element.

12. The system of claim 11, wherein the ALC element comprises a switch matrix that distributes the electrical stimulation pulses to selected electrodes of the plurality of electrodes.

13. The system of claim 11, further comprising a wire connected to the controller and the ALC element.

14. The system of claim 11, wherein the controller comprises an implantable pulse generator.

15. The system of claim 1, wherein the means for electronically addressing the plurality of electrodes comprises means for switching outputs from a pulse generator across one or more electrodes of the plurality of electrodes to deliver stimulation pulses.

16. The system of claim 1, wherein the at least one thin film at least partially overlaps the interposing element, and wherein the interposing element overlaps a portion of the feed-through element comprising the plurality of feed-through pins.

17. An assembly comprising:

at least one thin film for a lead of a probe, the thin film comprising a proximal end and a distal end, and wherein a plurality of electrodes are disposed on the distal end of the thin film; and

an Advanced Lead Connector (ALC) element configured to electronically address the plurality of electrodes, the ALC element comprising a feed-through element and a plurality of feed-through pins through the feed-through element configured to connect the ALC element with an interposing element; and

the interposing element configured to form an electrical connection between the plurality of electrodes and the ALC element via the plurality of feed-through pins through the feed-through element, at least a portion of the interposing element disposed between the proximal end of the thin film and the plurality of feed-through pins, wherein a first plurality of connections between the proximal end of the thin film and the interposing element defines a first footprint smaller than a second footprint defined by a second plurality of connections between the interposing element and the plurality of feed-through pins through the feed-through element of the ALC element, and wherein the first plurality of connections and the second plurality of connections are disposed at least partially through the interposing element.

18. The assembly of claim 17, wherein the ALC element comprises a switch matrix configured to switch outputs from a pulse generator across one or more electrodes of the plurality of electrodes.

19. The assembly of claim 17, wherein the first plurality of connections comprises, for each of the plurality of electrodes, a conductive glue configured to electrically connect the distal end of the thin film and the interposing element.

20. The assembly of claim 17, wherein the second plurality of connections comprises, for each of the plurality of electrodes, a respective feed-through pin of the plurality of feed-through pins configured to electrically connect the ALC element to the interposing element.

21. A method of manufacturing a probe, the probe comprising at least one thin film and an Advanced Lead Connector (ALC) element, the thin film comprising a proximal end and a distal end, the probe further comprising a plurality of electrodes on the distal end of the thin film, and the ALC element comprising electronic means for addressing the plurality of electrodes, a feed-through element, and a plurality of feed-through pins through the feed-through element configured to connect the ALC element with an interposing element, wherein the method comprises:

electrically coupling the plurality of feed-through pins through the feed-through element to an interposing element to form one or more first connections, the one or more first connections disposed at least partially through the interposing element; and

electrically coupling the proximal end of the thin film to the interposing element to form one or more second connections, the one or more second connections disposed at least partially through the interposing element, and the one or more first connections and the one or more second connections forming at least electric and/or electronic connections between the plurality of electrodes and the ALC element, wherein the one or more second connections define a first footprint smaller than a second footprint defined by the one or more first connections, and wherein the interposing element is at least partially between the proximal end of the thin film and the plurality of feed-through pins.