Enhanced dorsal horn stimulation using multiple electrical fields

• US 9,662,495 B2
• Filed: 07/22/2015
• Issued: 05/30/2017
• Est. Priority Date: 07/24/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Zhu, Changfang, Hershey, Bradley Lawrence, Moffitt, Michael A.
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US14/805,741
• Publication Number:
  US 20160022994A1
• Time in Patent Office: 678 Days
• Field of Search: 607 46
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/36192 Amplitude modulation

Abstract

A method of providing therapy to a patient having a medical condition comprises delivering electrical stimulation energy to the spinal cord of the patient in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord. The delivered electrical stimulation energy generates a plurality of electrical fields having different orientations that stimulate the dorsal horn neuronal elements.

Claims

1. A method, comprising:

providing therapy using implanted electrodes to a patient having a medical condition, wherein the providing therapy to the patient includes delivering electrical stimulation energy as a pulsed electrical waveform to a spinal cord of the patient in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord, wherein delivering electrical stimulation energy includes generating a plurality of electrical fields having different orientations at different times to stimulate the dorsal horn neuronal elements, and wherein generating the plurality of electrical fields having different orientations at different times includes generating a first electrical field having a first orientation during at least a first pulse in the pulsed electrical waveform, generating a second electrical field having a second orientation during at least a second pulse in the pulsed electrical waveform, and generating a third electrical field having a third orientation during at least a third pulse in the pulsed electrical waveform, the first, second and third orientations being different from each other.

2. The method of claim 1, wherein the electrical stimulation energy is delivered to the spinal cord of the patient without creating a sensation of paresthesia in the patient.

3. The method of claim 1, wherein the plurality of electrical fields are respectively generated on a pulse-by-pulse basis to provide different electric fields having different orientations during successive pulses.

4. The method of claim 1, wherein the plurality of electrical fields achieve temporal summation of stimulation in the dorsal horn neuronal elements.

5. The method of claim 1, wherein the electrical stimulation energy is delivered from an electrical stimulation lead implanted along a longitudinal axis of the spinal cord of the patient.

6. The method of claim 1, wherein the plurality of electrical fields are orientated in different medio-lateral directions or orientated in different rostro-caudal directions.

7. The method of claim 1, wherein each of the plurality of electrical fields are generated in an electrical field cycle, the method further comprising repeating the electrical field cycle multiple times.

8. The method of claim 7, wherein the electrical fields are generated a same number of pulses in each electrical field cycle.

9. The method of claim 7, wherein the electrical fields are generated a different number of pulses in each electrical field cycle.

10. The method of claim 7, wherein the electrical fields are generated in a same order during the electrical field cycles.

11. The method of claim 7, wherein the electrical fields are generated in a different order during the electrical field cycles.

12. The method of claim 7, wherein the electrical field cycles are bursted on and off at a burst frequency.

13. The method of claim 1, wherein the delivered electrical stimulation energy is anodic.

14. The method of claim 1, wherein the electrical stimulation energy is delivered from a plurality of electrodes implanted adjacent the spinal cord of the patient.

15. The method of claim 14, wherein the electrodes are radially segmented electrodes.

16. The method of claim 14, further comprising determining a stimulation threshold for each of the electrodes, and generating each of the electrical fields based on the stimulation thresholds of the electrodes.

17. The method of claim 16, wherein determining the stimulation threshold for each of the electrodes comprises automatically delivering electrical energy from each of the electrodes at different amplitudes, automatically measuring an evoked compound action potential in response to the deliverance of the electrical energy from each of the electrodes, and automatically recording the amplitude at which the evoked compound action potential is measured for each of the electrodes.

18. The method of claim 16, wherein determining the stimulation threshold for each of the electrodes comprises automatically delivering electrical energy from each of the electrodes at different amplitudes, acquiring feedback from the patient in response to the deliverance of the electrical energy from each of the electrodes, and automatically recording the amplitude at which paresthesia is perceived by the patient for each of the electrodes.

19. The method of claim 1, wherein the medical condition is chronic pain.

20. An implantable system for providing therapy to a patient using electrodes, comprising:

a programmable device programmed with a stimulation program to provide therapy using the electrodes to the patient having a medical condition by delivering electrical stimulation energy as a pulsed electrical waveform to a spinal cord of the patient in accordance with the stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord, wherein the programmable device programmed with the stimulation program is configured to generate a plurality of electrical fields having different orientations at different times to stimulate the dorsal horn neuronal elements, including a first electrical field having a first orientation during at least a first pulse in the pulsed electrical waveform, a second electrical field having a second orientation during at least a second pulse in the pulsed electrical waveform, and a third electrical field having a third orientation during at least a third pulse in the pulsed electrical waveform, the first, second and third orientations being different from each other.