Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections

• US 9,663,474 B2
• Filed: 11/15/2013
• Issued: 05/30/2017
• Est. Priority Date: 11/16/2012
• Status: Active Grant

• Current Assignee: Janssen Sciences Ireland Unlimited Company (Johnson & Johnson)
• Original Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Inventors: Embrechts, Werner, Last, Stefaan Julien, McGowan, David Craig, Jonckers, Tim Hugo Maria, Raboisson, Pierre Jean-Marie Bernard, Pieters, Serge Maria Aloysius
• Primary Examiner(s): Ward, Paul V
• Application Number:
  US14/443,305
• Publication Number:
  US 20150284339A1
• Time in Patent Office: 1,292 Days
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 239/84 Nitrogen atoms
• CPC Class Codes: C07D 239/95 with hetero atoms directly attached in positions 2 and 4
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links

Abstract

This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Claims

1. A compound of formula (I)

3. A compound of claim 1, wherein R₁ is

4. A compound as claimed in claim 1, wherein R₉ is CH₃.

5. A compound as claimed in claim 1, wherein R₂ is OCH₃ or —

O—

(C_1-3)-alkyl-O—

(C_1-3)-alkyl.

6. A compound as claimed in claim 1, wherein

R₃, R₄, R₁₃ and R₈ are each H;

R₉ is CH₃;

R₂ is —

O—

(C_1-3)-alkyl-O—

(C_1-3)-alkyl; and

R₁ is

7. A compound as claimed in claim 1, wherein

R₃, R₄, R₁₃ and R₈ are each H;

R₉ is CH₃;

R₂ is OCH₃; and

R₁ is

8. A compound as claimed in claim 1, said compound selected from the group consisting of

9. A pharmaceutical composition comprising a compound as claimed in claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.

2. A substituted 2-amino-4-hydroxyquinazoline having the following formula