RNA sequences that induce fluorescence of small molecule fluorophores
First Claim
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1. A nucleic acid molecule comprising the nucleotide sequence of:
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Abstract
The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
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16 Claims
- 1. A nucleic acid molecule comprising the nucleotide sequence of:
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