Fluid handling apparatus and configurations
First Claim
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1. A sample processing apparatus for use with a biological sample and/or a reagent, comprising:
- a sample preparation station, assay station, and/or detection station;
a control unit having a processor that is programmed to execute computer-readable commands; and
a modular sample handling system having at least a first pipette body and a second pipette body each mounted on a common support structure, wherein at least one of the first pipette body and the second pipette body is independently movable and independently controllable in relation to the other, wherein the first and second pipette bodys comprise internal actuation mechanisms that are independently movable within the pipette bodys, and wherein the sample handling system transfers the biological sample or the reagent from or to one or more of said stations;
wherein each of the first pipette body and the second pipette body comprises;
a pipette nozzle, a motor, geartrain, valve, lead screw, and piston, wherein each of foregoing is movable with the pipette body as one-piece between a first position and a second position relative to the common support structure.
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Abstract
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
540 Citations
19 Claims
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1. A sample processing apparatus for use with a biological sample and/or a reagent, comprising:
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a sample preparation station, assay station, and/or detection station; a control unit having a processor that is programmed to execute computer-readable commands; and a modular sample handling system having at least a first pipette body and a second pipette body each mounted on a common support structure, wherein at least one of the first pipette body and the second pipette body is independently movable and independently controllable in relation to the other, wherein the first and second pipette bodys comprise internal actuation mechanisms that are independently movable within the pipette bodys, and wherein the sample handling system transfers the biological sample or the reagent from or to one or more of said stations; wherein each of the first pipette body and the second pipette body comprises;
a pipette nozzle, a motor, geartrain, valve, lead screw, and piston, wherein each of foregoing is movable with the pipette body as one-piece between a first position and a second position relative to the common support structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An apparatus for receiving, processing and/or analyzing a biological sample, comprising:
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a sample preparation station, assay station, and/or detection station, each of which being identified by an individually addressable location within or amongst the stations; a control unit having a processor that is programmed to execute computer-readable commands; and a sample handling system having at least a first pipette head and a second pipette body each mounted on a support structure, bodies of which first pipette body and second pipette body are independently movable in relation to one another, each of said first pipette body and said second pipette body having a pipette nozzle configured to connect with a removable tip, wherein one of said first pipette body and second pipette body is configured to connect with a tip of different size and/or shape than the other of the first pipette body and second pipette body, wherein the first and second pipette bodys comprise internal actuation mechanisms that are independently movable within the pipette bodys, wherein each of the first pipette body and the second pipette body comprises;
a pipette nozzle, a motor, geartrain, valve, lead screw, and piston, wherein each of foregoing is movable with the pipette body as one-piece between a first position and a second position relative to the support structure. - View Dependent Claims (11, 12, 13, 14)
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15. An apparatus for handling a fluid, comprising:
a supporting body, extending therefrom a plurality of pipette heads comprising; a positive displacement pipette body, comprising a positive displacement pipette nozzle configured to connect with a first removable tip; and an air displacement pipette body, comprising an air displacement pipette nozzle configured to connect to an air displacement pipette tip, wherein said positive displacement pipette body and air displacement pipette body are independently movable in relation to one another, wherein the positive displacement pipette head and air displacement pipette head comprise internal actuation mechanisms that are independently movable within the pipette bodys, and wherein at least one of the positive displacement pipette body and the air displacement pipette body comprises a plunger and an electromagnetic spectrum detection device, wherein the electromagnetic spectrum detection device is located at the end of the plunger, captures electromagnetic emission, and moves with the plunger each of the first pipette body and the second pipette body comprises;
a pipette nozzle, a motor, geartrain, valve, lead screw, and piston, wherein each of foregoing is movable with the pipette body as one-piece between a first position and a second position.- View Dependent Claims (16, 17, 18, 19)
Specification