System and method for reconstructing cardiac activation information
First Claim
1. A method of reconstructing cardiac activation information, the method comprising:
- accessing, by a computing device, an analysis cardiac signal and a reference cardiac signal obtained from a patient;
processing, by the computing device, the analysis cardiac signal and the reference cardiac signal to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal, the derivative of the analysis cardiac signal and the derivative of the reference cardiac signal being one of zero, first, and second order derivative;
processing, by the computing device, the analysis cardiac signal and the reference cardiac signal to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal diverges with respect to a different derivative of the reference cardiac signal, the different derivative of the analysis cardiac signal and the different derivative of the reference cardiac signal being a different one of zero, first, and second order derivative; and
assigning an activation onset time in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
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Abstract
In a system and method for reconstructing cardiac activation information, an analysis cardiac signal and a reference cardiac signal are accessed and processed to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal. The signals are processed to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal with respect to a different derivative of the reference cardiac signal. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.
234 Citations
37 Claims
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1. A method of reconstructing cardiac activation information, the method comprising:
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accessing, by a computing device, an analysis cardiac signal and a reference cardiac signal obtained from a patient; processing, by the computing device, the analysis cardiac signal and the reference cardiac signal to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal, the derivative of the analysis cardiac signal and the derivative of the reference cardiac signal being one of zero, first, and second order derivative; processing, by the computing device, the analysis cardiac signal and the reference cardiac signal to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal diverges with respect to a different derivative of the reference cardiac signal, the different derivative of the analysis cardiac signal and the different derivative of the reference cardiac signal being a different one of zero, first, and second order derivative; and assigning an activation onset time in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system to reconstruct cardiac activation information comprising:
at least one computing device configured to; access an analysis cardiac signal and a reference cardiac signal obtained from a patient; process the analysis cardiac signal and the reference cardiac signal to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal, the derivative of the analysis cardiac signal and the derivative of the reference cardiac signal being one of zero, first, and second order derivative; process the analysis cardiac signal and the reference cardiac signal to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal diverges with respect to a different derivative of the reference cardiac signal, the different derivative of the analysis cardiac signal and the different derivative of the reference cardiac signal being a different one of zero, first and second order derivative; and assign an activation onset time in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method of treating a cardiac rhythm disorder, the method comprising:
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iteratively accessing an analysis cardiac signal and a reference cardiac signal from a plurality of cardiac signals, the plurality of cardiac signals obtained from a patient; processing, by a computing device, the analysis cardiac signal and the reference cardiac signal to determine a first point of change in the analysis cardiac signal at which a derivative of the analysis cardiac signal diverges with respect to a derivative of the reference cardiac signal, the derivative of the analysis cardiac signal and the derivative of the reference cardiac signal being one of zero, first, and second order derivative; processing, by the computing device, the analysis cardiac signal and the reference cardiac signal to determine a second point of change in the analysis cardiac signal at which a different derivative of the analysis cardiac signal diverges with respect to a different derivative of the reference cardiac signal above a second threshold, the derivative of the different analysis cardiac signal and the different derivative of the reference cardiac signal being one of zero, first, and second order derivative; assigning activation onset times in the analysis cardiac signal at points based on a mathematical association of first points of change and second points of change to define cardiac activations indicating beats in the analysis cardiac signal; reconstructing a cardiac activation pattern based on the assigned activation onset times to indicate a source of the cardiac rhythm disorder; and treating cardiac tissue of the patient at the source to suppress or eliminate the cardiac rhythm disorder.
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Specification