Method and apparatus to measure bioelectric impedance of patient tissue

• US 9,668,667 B2
• Filed: 11/14/2014
• Issued: 06/06/2017
• Est. Priority Date: 04/18/2008
• Status: Active Grant

• Current Assignee: Medtronic Monitoring, Inc. (Medtronic Plc)
• Original Assignee: Medtronic Monitoring, Inc. (Medtronic Plc)
• Inventors: Mazar, Scott T.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US14/542,097
• Publication Number:
  US 20150073252A1
• Time in Patent Office: 935 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/259 using conductive adhesive means, e.g. gels
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 7/00 Instruments for auscultation

Abstract

A device to measure tissue impedance comprises drive circuitry coupled to calibration circuitry, such that a calibration signal from the calibration circuitry corresponds to the current delivered through the tissue. Measurement circuitry can be coupled to measurement electrodes and the calibration circuitry, such that the tissue impedance can be determined in response to the measured calibration signal from the calibration circuitry and the measured tissue impedance signal from the measurement electrodes. Processor circuitry comprising a tangible medium can be configured to determine a complex tissue impedance in response to the calibration signal and the tissue impedance signal. The processor can be configured to select a frequency for the drive current, and the amount of drive current at increased frequencies may exceed a safety threshold for the drive current at lower frequencies.

Claims

1. A device for measuring an electrocardiogram signal of a patient, the device comprising:

an adhesive patch that includes at least two electrodes configured to couple to the tissue of the patient;

an electronics module comprising electrocardiogram circuitry and a processor mounted on a flex printed circuit board (PCB), wherein the electrocardiogram circuitry is coupled to two or more of the at least two electrodes via electrical traces formed on the flex PCB, and the processor is programmed to receive and process the electrocardiogram signal measured from the patient; and

at least two connectors positioned in alignment with the at least two electrodes to connect the at least two electrodes to the traces formed on the flex PCB, wherein the at least two connectors are comprised of insulated wires.

2. The device of claim 1, wherein the adhesive patch and the electronics module are separable, and the adhesive patch can be replaced and the electronics module reused with multiple adhesive patches.

3. The device of claim 1, further comprising wireless communications circuitry that transmits data to a remote server.

4. The device of claim 1, wherein the electronics module further comprises one or more rigid printed circuit boards mounted on the flexible PCB, wherein at least some of the electronics are mounted on one or more of the rigid printed circuit boards.

5. The device of claim 1, wherein the electronics module further comprises:

an electronics housing;

a battery; and

a cover over the electronics housing, battery, and flex printed circuit board.

6. The device of claim 1, further comprising a flexible, breathable cover over the electronics module.

7. The device of claim 1, further comprising wireless communications circuitry that transmits data to a remote server.

8. The device of claim 1, wherein the at least two electrodes comprise at least four electrodes, wherein at least two of the electrodes are measurement electrodes and at least two of the electrodes are drive electrodes.

9. The device of claim 8, further including:

calibration circuitry;

drive circuitry coupled to the at least two drive electrodes and the calibration circuitry to pass a current through the tissue and the calibration circuitry simultaneously; and

measurement circuitry configured to couple to the at least two measurement electrodes and the calibration circuitry, the measurement circuitry configured to measure a calibration signal from the calibration circuitry and a tissue impedance signal from the at least two measurement electrodes, wherein the processor is programmed to receive and process the signal measured from the two measurement electrodes to determine a tissue impedance of the patient.

10. A device for measuring an electrocardiogram signal of a patient, the device comprising:

an adhesive patch that includes at least four electrodes configured to couple to the tissue of the patient, wherein at least two of the electrodes are measurement electrodes and at least two of the electrodes are drive electrodes; and

an electronics module comprising electrocardiogram circuitry coupled to two or more of the at least two electrodes, and a processor programmed to receive and process the electrocardiogram signal measured from the patient;

wherein the adhesive patch and the electronics module are separable.

11. The device of claim 10, further including:

calibration circuitry;

drive circuitry coupled to the at least two drive electrodes and the calibration circuitry to pass a current through the tissue and the calibration circuitry simultaneously; and

measurement circuitry configured to couple to the at least two measurement electrodes and the calibration circuitry, the measurement circuitry configured to measure a calibration signal from the calibration circuitry and a tissue impedance signal from the at least two measurement electrodes, wherein the processor is programmed to receive and process the signal measured from the two measurement electrodes to determine a tissue impedance of the patient.

12. The device of claim 10, wherein the electronics module further comprises a flex printed circuit board on which at least some of the electronics are mounted.

13. The device of claim 12, further including a plurality of connectors positioned on the flex printed circuit board positioned in alignment with at least two electrodes to electrically couple the at least two electrodes to the flex printed circuit board.

14. The device of claim 13, wherein the plurality of connectors include insulated wires to provide strain relief between the at least two electrodes and the flex printed circuit board.

15. The device of claim 13, further including one or more rigid printed circuit boards (PCBs) are connected to the flex printed circuit board.

16. The device of claim 13, wherein the electronics module is connected to the flex printed circuit board.