Method for data reduction and calibration of an OCT-based physiological monitor
First Claim
1. A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:
- receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times;
computing intensity differences between the at least two OCT scans to generate an intensity difference plot;
selecting, based on one or more portions of the intensity difference plot having large changes in intensity, corresponding one or more portions of the at least two OCT scans having large changes in intensity; and
estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data.
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Abstract
The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.
934 Citations
14 Claims
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1. A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:
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receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times; computing intensity differences between the at least two OCT scans to generate an intensity difference plot; selecting, based on one or more portions of the intensity difference plot having large changes in intensity, corresponding one or more portions of the at least two OCT scans having large changes in intensity; and estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data. - View Dependent Claims (2, 3, 4, 5)
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6. A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:
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receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times; identifying at least one discontinuity in data associated with the at least two OCT scans; selecting one or more portions of the at least two OCT scans corresponding to the at least one discontinuity; and estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A method of estimating a blood analyte level using an optical coherence tomography (OCT) device, the method comprising:
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receiving, from an OCT device, at least two OCT scans of an area of biological tissue along a depth dimension, the at least two OCT scans obtained at different times; generating a Pearson plot to indicate correlations between a plurality of OCT measurements at a plurality of portions and depths of the at least two OCT scans; and determining a first depth based on the Pearson plot; selecting one or more portions of the at least two OCT scans corresponding to the first depth; and estimating a blood analyte level based on a comparison of the one or more portions of the at least two OCT scans with OCT calibration data. - View Dependent Claims (13, 14)
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Specification