Method and system for quantifying limitations in coronary artery blood flow during physical activity in patients with coronary artery disease
First Claim
1. A system for determining information for a patient, the system comprising:
- at least one computer system configured to;
receive data describing a geometry of at least a portion of the patient'"'"'s heart;
determine a three-dimensional model representing the geometry of at least the portion of the patient'"'"'s heart based on the received data;
identify a cardiac event and a blood flow characteristic threshold value associated with the cardiac event;
determine a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient, the physics-based model including a resistance to blood flow at the patient'"'"'s myocardium and the selected level of physical activity being selected from a plurality of physical activity levels;
model the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity;
calculate, from the modeled flow of blood through the three-dimensional model simulated at the selected level of physical activity, a value of the blood flow characteristic within the patient'"'"'s heart at the selected level of physical activity;
update the physics-based model of blood flow by reducing the resistance to blood flow at the patient'"'"'s myocardium through iteratively increasing levels of physical activity;
model the flow of blood through the updated physics-based model simulated at a level of the iteratively increasing levels of physical activity that is higher than the selected level of physical activity;
recalculate a value of the blood flow characteristic within the patient'"'"'s heart at the level of physical activity higher than the selected level of physical activity to identify a recalculated value of the blood flow characteristic that exceeds the blood flow characteristic threshold value associated with the cardiac event;
determine a maximum level of physical activity, intensity, or exercise for the patient based on the level of physical activity at which the recalculated value of the blood flow characteristic exceeds the blood flow characteristic threshold value associated with the cardiac event; and
determine one or more physical activity recommendations for treatment of the patient based on the determined maximum level of physical activity, intensity, or exercise for the patient.
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Accused Products
Abstract
Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart and create a model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient'"'"'s heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient'"'"'s heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.
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Citations
27 Claims
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1. A system for determining information for a patient, the system comprising:
at least one computer system configured to; receive data describing a geometry of at least a portion of the patient'"'"'s heart; determine a three-dimensional model representing the geometry of at least the portion of the patient'"'"'s heart based on the received data; identify a cardiac event and a blood flow characteristic threshold value associated with the cardiac event; determine a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient, the physics-based model including a resistance to blood flow at the patient'"'"'s myocardium and the selected level of physical activity being selected from a plurality of physical activity levels; model the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity; calculate, from the modeled flow of blood through the three-dimensional model simulated at the selected level of physical activity, a value of the blood flow characteristic within the patient'"'"'s heart at the selected level of physical activity; update the physics-based model of blood flow by reducing the resistance to blood flow at the patient'"'"'s myocardium through iteratively increasing levels of physical activity; model the flow of blood through the updated physics-based model simulated at a level of the iteratively increasing levels of physical activity that is higher than the selected level of physical activity; recalculate a value of the blood flow characteristic within the patient'"'"'s heart at the level of physical activity higher than the selected level of physical activity to identify a recalculated value of the blood flow characteristic that exceeds the blood flow characteristic threshold value associated with the cardiac event; determine a maximum level of physical activity, intensity, or exercise for the patient based on the level of physical activity at which the recalculated value of the blood flow characteristic exceeds the blood flow characteristic threshold value associated with the cardiac event; and determine one or more physical activity recommendations for treatment of the patient based on the determined maximum level of physical activity, intensity, or exercise for the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for determining information for a patient using at least one computer system, the method comprising:
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receiving, at the at least one computer system, data describing a geometry of at least a portion of the patient'"'"'s heart; determining, using the at least one computer system, a three-dimensional model representing the geometry of at least the portion of the patient'"'"'s heart based on the received data; identifying a cardiac event and a blood flow characteristic threshold value associated with the cardiac event; determining, using the at least one computer system, a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient the physics-based model including a resistance to blood flow at the patient'"'"'s myocardium and the selected level of physical activity being selected from a plurality of physical activity levels; modeling the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity; calculating, from the modeled flow of blood through the three-dimensional model simulated at the selected level of physical activity, a value of the blood flow characteristic within the patient'"'"'s heart at the selected level of physical activity; updating the physics-based model of blood flow by reducing the resistance to blood flow at the patient'"'"'s myocardium through iteratively increasing levels of physical activity; modeling the flow of blood through the updated physics-based model simulated at a level of the iteratively increasing levels of physical activity that is higher than the selected level of physical activity; recalculating a value of the blood flow characteristic within the patient'"'"'s heart at the level of physical activity higher than the selected level of physical activity to identify a recalculated value of the blood flow characteristic that exceeds the blood flow characteristic threshold value associated with the cardiac event; determining a maximum level of physical activity, intensity, or exercise for the patient based on the level of physical activity at which the recalculated value of the blood flow characteristic exceeds the blood flow characteristic threshold value associated with the cardiac event; and determining one or more physical activity recommendations for treatment of the patient based on the determined maximum level of physical activity, intensity, or exercise for the patient. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A non-transitory computer readable medium for use on at least one computer system containing computer-executable programming instructions for performing a method for determining information for a patient, the method comprising:
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receiving describing a geometry of at least a portion of the patient'"'"'s heart; determining a three-dimensional model representing the geometry of at least the portion of the patient'"'"'s heart based on the received data; identifying a cardiac event and a blood flow characteristic threshold value associated with the cardiac event; determining a physics-based model of blood flow through the three-dimensional model simulated at a selected level of physical activity of the patient the physics-based model including a resistance to blood flow at the patient'"'"'s myocardium and the selected level of physical activity being selected from a plurality of physical activity levels; modeling the flow of blood through the three-dimensional model using the physics-based model of blood flow through the three-dimensional model simulated at the selected level of physical activity; calculating, from the modeled flow of blood through the three-dimensional model simulated at the selected level of physical activity, a value of the blood flow characteristic within the patient'"'"'s heart at the selected level of physical activity; updating the physics-based model of blood flow by reducing the resistance to blood flow at the patient'"'"'s myocardium through iteratively increasing levels of physical activity; modeling the flow of blood through the updated physics-based model simulated at a level of the iteratively increasing levels of physical activity that is higher than the selected level of physical activity; recalculating a value of the blood flow characteristic within the patient'"'"'s heart at the level of physical activity higher than the selected level of physical activity to identify a recalculated value of the blood flow characteristic that exceeds the blood flow characteristic threshold value associated with the cardiac event; determining a maximum level of physical activity, intensity, or exercise for the patient based on the level of physical activity at which the recalculated value of the blood flow characteristic exceeds the blood flow characteristic threshold value associated with the cardiac event; and determining one or more physical activity recommendations for treatment of the patient based on the determined maximum level of physical activity, intensity, or exercise for the patient. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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Specification