Minimally invasive access for renal nerve ablation

• US 9,668,811 B2
• Filed: 09/23/2011
• Issued: 06/06/2017
• Est. Priority Date: 11/16/2010
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Sogard, David J., Smith, Scott, Jenson, Mark L.
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): NGUYEN, HIEN NGOC
• Application Number:
  US13/243,134
• Publication Number:
  US 20120123303A1
• Time in Patent Office: 2,083 Days
• Field of Search: 601 2
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 90/37 Surgical systems with images on a monitor during operation
• CPC Class Codes: A61N 2007/003 Destruction of nerve tissue
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/067 using laser light
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

An elongated flexible medical device is inserted into a patient'"'"'s body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

Claims

1. A method, comprising:

inserting an elongated flexible medical device into a patient'"'"'s body via a natural orifice;

wherein the natural orifice includes a urethra;

advancing the medical device through the urethra, through the bladder, and through a ureter to a location proximate innervated tissue that influences renal sympathetic nerve activity; and

delivering energy from a distal end of the medical device to one or both of image and ablate the innervated tissue.

2. The method of claim 1, wherein delivering energy from the distal end of the medical device comprises delivering energy of sufficient power or intensity to one or both of ablate the innervated tissue and image the innervated tissue.

3. The method of claim 1, wherein delivering energy from the distal end of the medical device comprises delivering energy of sufficient power or intensity to selectively image the innervated tissue and ablate the innervated tissue.

4. The method of claim 1, wherein delivering energy from the distal end of the medical device comprises delivering energy of sufficient power or intensity to ablate the innervated tissue, the method further comprising imaging tissue of or proximate the innervated tissue using an external imaging device to facilitate ablation of the innervated tissue by the medical device.

5. The method of claim 1, wherein delivering energy from the distal end of the medical device comprises ablating the innervated tissue using at least one of RF energy, ultrasound energy, optical energy, and thermal energy.

12. The method of claim 1, wherein advancing the medical device through the natural orifice, through the bladder, and into a ureter to a location proximate innervated tissue that influences renal sympathetic nerve activity includes advancing the medical device to a position adjacent to a renal artery.

6. An apparatus, comprising:

an elongated flexible medical device configured for insertion into a patient'"'"'s body via a natural orifice, the medical device being configured for and having a length sufficient for advancement through a urethra, through a bladder, and through a ureter to a position adjacent to a renal artery proximate innervated tissue that influences renal sympathetic nerve activity via an internal body pathway of the patient; and

an energy delivery device provided at a distal end of the medical device and configured to communicate energy to the location at or proximate the innervated tissue to one or both of image and ablate the innervated tissue.

7. The apparatus of claim 6, wherein the energy delivery device comprises one or both of an ablation device configured to ablate the innervated tissue and an imaging device configured to image the innervated tissue.

8. The apparatus of claim 6, wherein the energy delivery device comprises a device configured to selectively image the innervated tissue and ablate the innervated tissue.

9. The apparatus of claim 6, wherein the energy delivery device comprises at least one of a radiofrequency ablation device, an ultrasound ablation device, an optical ablation device, and a thermal ablation device.

10. The apparatus of claim 6, further comprising:

a second elongated flexible medical device configured for insertion into the patient'"'"'s body and having a length sufficient for advancement to a second location at or proximate innervated tissue relative to a body access location of the patient; and

a second energy device provided at a distal end of the second medical device.

11. The apparatus of claim 10, wherein the energy delivery device comprises an ablation device and the second energy delivery device comprises an imaging device.