Mesh implant for use in reconstruction of soft tissue defects

• US 9,668,847 B2
• Filed: 06/24/2014
• Issued: 06/06/2017
• Est. Priority Date: 06/22/2006
• Status: Active Grant

• Current Assignee: Novus Scientific AB (Novus Scientific Pte., Ltd.)
• Original Assignee: Novus Scientific AB (Novus Scientific Pte., Ltd.)
• Inventors: Mathisen, Torbjrn, Magnusson, Henrik
• Primary Examiner(s): Anderson, Gregory
• Assistant Examiner(s): LAUER, CHRISTINA C
• Application Number:
  US14/313,423
• Publication Number:
  US 20140303655A1
• Time in Patent Office: 1,078 Days
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes

Abstract

The present invention relates to a resorbable polymeric mesh implant, that is intended to be used in the reconstruction of soft tissue defects. The mesh implant comprises at least a first and a second material, wherein the second material is substantially degraded at a later point in time than the first material following the time of implantation. The mesh implant is adapted to have a predetermined modulus of elasticity that gradually is decreased until the mesh implant is completely degraded and subsequently resorbed. Due to the gradual decrease in the modulus of elasticity of the inventive mesh implant, the regenerating tissue may gradually take over the load applied to the tissue defect area.

Claims

1. A resorbable polymeric mesh implant whose implant configuration varies over time after implantation for use in reconstruction of soft tissue, wherein the resorbable polymeric mesh implant comprises:

at least a first material and a second material,

wherein the second material is substantially degraded at a later point in time than the first material,

wherein the modulus of elasticity of the mesh implant is initially substantially constant, allowing an elongation of ≦

10% when subjected to a load of 16 N/cm, following a time of implantation and until said first material is substantially degraded,

wherein the modulus of elasticity of the mesh implant substantially decreases after the first material is substantially degraded.

2. A resorbable polymeric mesh implant according to claim 1, wherein the mesh implant is configured for use in reconstruction of soft tissue defects.

3. A resorbable polymeric mesh implant according to claim 1, wherein the first substantially degraded material is substantially degraded at a point in time within a time range of 2-13 days following implantation.

4. A resorbable polymeric mesh implant according to claim 1, wherein the elongation of the mesh implant is in a range of 18 to 32%, when subjected to a load of 16 N/cm, after the first material has substantially degraded.

5. A resorbable polymeric mesh implant according to claim 1, wherein the mesh implant further comprises a third material that is substantially degraded at a later point in time than the second material, wherein the modulus of elasticity of the mesh implant is substantially equal to a modulus of elasticity of the third material in the implant configuration after the second material is substantially degraded.

6. A resorbable polymeric mesh implant according to claim 1, wherein the last substantially degraded material has a modulus of elasticity in the implant configuration that is compatible with the elasticity of surrounding tissue so that a flexibility of said tissue is not substantially restricted.

7. A resorbable polymeric mesh implant according to claim 1, wherein a last substantially degraded material is substantially degraded at a point in time within a time range of 3-18 months following implantation.

8. A resorbable polymeric mesh implant according to claim 1, wherein materials are chosen in order to construct a mesh implant that is tailored for a specific soft tissue to be reconstructed.

9. A resorbable polymeric mesh implant according to claim 1, wherein the mesh implant is provided with a resorbable film in order to prevent adhesion of the mesh implant to surrounding tissue.

10. A resorbable polymeric mesh implant according to claim 9, wherein the resorbable film is a hydrophilic carbohydrate film.

11. A resorbable polymeric mesh implant according to claim 1, wherein the first material and/or the second material has a porous structure with a pore size in the range of 50-4000 microns.

12. A resorbable polymeric mesh implant according to claim 1, wherein the first material and/or the second material has or is incorporated into a non-woven structure.

13. A resorbable polymeric mesh implant according to claim 1, wherein the last substantially degraded material has a pore size in the range of 0.5-4 mm.

14. A resorbable polymeric mesh implant according to claim 1, wherein the first material comprises glycolide/ε

-caprolactone.

15. A resorbable polymeric mesh implant according to claim 1, wherein the first material comprises glycolide/ε

-caprolactone and the second material comprises lactide/ε

-caprolactone/trimethylene-carbonate.

16. A resorbable polymeric mesh implant according to claim 1, wherein the second material comprises lactide/ε

-caprolactone/trimethylene-carbonate.

17. A resorbable polymeric mesh implant whose implant configuration varies over time after implantation for use in reconstruction of soft tissue, wherein the resorbable polymeric mesh implant comprises:

at least a first material and a second material,

wherein the second material is substantially degraded at a later point in time than the first material,

wherein the modulus of elasticity of the mesh implant is initially substantially constant, allowing an elongation of ≦

10% when subjected to a load of 16 N/cm, following a time of implantation and until said first material is substantially degraded,

wherein the modulus of elasticity of the mesh implant substantially decreases after the first material is substantially degraded,

wherein the area weight of the mesh implant is 20 to 300 g/m² in its dry state.

18. A resorbable polymeric mesh implant whose implant configuration varies over time after implantation for use in reconstruction of soft tissue, wherein the resorbable polymeric mesh implant comprises:

at least a first material and a second material,

wherein the second material is substantially degraded at a later point in time than the first material,

wherein the modulus of elasticity of the mesh implant is initially substantially constant, allowing an elongation of ≦

10% when subjected to a load of 16 N/cm, following a time of implantation and until said first material is substantially degraded,

wherein the modulus of elasticity of the mesh implant substantially decreases after the first material is substantially degraded,

wherein the area weight of the mesh implant is 30 to 150 g/m² in its dry state.