Systems and methods for compounding a preparation using a premix solution

• US 9,668,940 B2
• Filed: 10/25/2016
• Issued: 06/06/2017
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Original Assignee: Baxter Corporation Englewood (Baxter International Inc.)
• Inventors: Kaucky, Dennis, Tribble, Dennis A.
• Primary Examiner(s): SOOHOO, TONY GLEN
• Application Number:
  US15/333,410
• Publication Number:
  US 20170035655A1
• Time in Patent Office: 224 Days
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 33/846 using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles
• CPC Class Codes: B01F 35/2206 Use of stored recipes for controlling the computer programs, e.g. for manipulation, handling, production or composition in mixing plants B01F33/846 takes precedence
• CPC Class Codes: B01F 35/2207 Use of data, i.e. barcodes, 3D codes or similar type of tagging information, as instruction or identification codes for controlling the computer programs, e.g. for manipulation, handling, production or compounding in mixing plants B01F33/848 takes precedence
• CPC Class Codes: B01F 35/717611 Peristaltic pumps
• CPC Class Codes: G05D 11/133 with discontinuous action

Abstract

Computer systems and non-transitory computer readable media for determining an amount of an ingredient for a preparation for a requested therapy (e.g., an order or a prescription) includes an identifier, volume, and amounts of first and second compounds in each of a plurality of premix solutions. A predefined formulary comprising a formulary concentration of each of a plurality of additions is provided. A premix solution is selected. An amount of a first additions to be added to the premix solution may be selected. A number of bags of the premix solution, needed to satisfy a volume associated with the selected premix solution, are optionally reserved. An additive volume is determined at least by the specified first amounts of the first addition and a corresponding formulary concentration.

Claims

1. A method for use of an automatic compounder for compounding a preparation corresponding to a requested therapy to be administered to a patient, the method comprising:

receiving, at the compounder, a manifest corresponding to the preparation to be compounded, wherein the manifest comprises an indication of a receiving receptacle that contains a volume of at least a first component for inclusion in the preparation, and wherein the manifest comprises an indication of an amount of at least one additive to be added to the receiving receptacle;

establishing fluid interconnection between a delivery port of the compounder and the receiving receptacle and between an input port of the compounder and an additive receptacle containing the additive to be added to the receiving receptacle, wherein the receiving receptacle comprises a prepackaged container containing the volume of at least the first component;

delivering, using a preprogrammed logic of the compounder, the amount of the additive from the additive receptacle to the receiving receptacle at least partially based on the manifest, wherein the preprogrammed logic of the compounder automatically controls flow from the input port to the delivery port;

receiving the receiving receptacle at a receptacle support of the compounder;

measuring, at the compounder in response to receiving the receiving receptacle, at least one beginning physical property of the receiving receptacle prior to the delivering; and

comparing, using the preprogrammed logic, the least one beginning physical property of the receiving receptacle measured by the compounder to an expected physical property for the receiving receptacle.

2. The method of claim 1, wherein the manifest comprises an indication of an amount for each of a plurality of additives to be added to the receiving receptacle.

3. The method of claim 2, further comprising sequencing, using the preprogrammed logic, the delivery of the plurality of additives to reduce interaction of potentially incompatible ingredients.

4. The method of claim 1, wherein the establishing further comprises establishing fluid interconnection between a plurality of additive receptacles corresponding to the plurality of additives and a plurality of respective input ports of the compounder.

5. The method of claim 4, wherein the delivering further comprises selectively controlling flow from each of said plurality of input ports and the delivery port to deliver the amount of each of the plurality of additives at least partially based on the manifest.

6. The method of claim 5, further comprising:

maintaining the fluid interconnection between the delivery port of the compounder and the receiving receptacle during the delivering of the amount of each of the plurality of additives.

7. The method of claim 6, wherein the establishing comprises a first fluid interconnection between the delivery port of the compounder and the receiving receptacle.

8. The method of claim 7, wherein the receiving receptacle comprises a premix solution comprising a parenteral nutrition (PN) solution.

9. The method of claim 1, wherein the delivering is performed in an at least partially automated fashion by the compounder.

10. The method of claim 1, further comprising:

retrieving, with the preprogrammed logic from a memory at the compounder, a headspace measure for the receiving receptacle, wherein the headspace measure is at least partially based on the volume of the first component in the receiving receptacle and a total predetermined available volume of the receiving receptacle.

11. The method of claim 10, wherein the headspace measure comprises the volume difference between the total predetermined available volume of the receiving receptacle and the volume of the first component in the receiving receptacle.

12. The method of claim 1, further comprising:

maintaining, in the memory at the compounder, a description of a plurality of receiving receptacles, wherein the description comprises information related to at least one of a headspace volume measure, a predetermined total available volume, a first component, and a beginning physical property for each of the plurality of receiving receptacles.

13. The method of claim 12, wherein the indication of the receiving receptacle of the manifest corresponds to one of the plurality of receiving receptacles for which a description is maintained in the memory at the compounder.

14. The method of claim 13, further comprising:

comparing, using the preprogrammed logic, the headspace volume measure to the sum of the amounts of the plurality of additives.

15. The method of claim 14, further comprising:

generating an alert at the compounder when sum of the amounts of the plurality of amounts of additives exceeds the headspace volume measure.

16. The method of claim 12, further comprising:

analyzing, after the delivering using the preprogrammed logic, at least one ending physical property of the receiving receptacle that is determined at the compounder to an expected ending physical property, wherein the expected ending physical property is at least partially based on the beginning physical property and the plurality of amounts of additives.

17. The method of claim 1, further comprising:

obtaining, at the compounder, information indicative of the identity of the received receiving receptacle prior to the establishing.

18. The method of claim 17, wherein the obtaining includes reading, with the compounder, a machine readable indicia corresponding to the receiving receptacle.

19. The method of claim 18, wherein the machine readable indicia comprises one of an RFID tag or a bar code physically provided with the receiving receptacle.

20. The method of claim 18, wherein the machine readable indicia corresponding to the received receiving receptacle is compared, using the preprogrammed logic, to the indication of the receiving receptacle from the manifest to verify a received receiving receptacle corresponds to the indication of the receiving receptacle.

21. The method of claim 1, wherein the receiving of the manifest comprises accepting inputs from a user by way of manual user inputs at a user interface at the compounder.

22. The method of claim 1, wherein the receiving of the manifest comprises obtaining a manifest output corresponding to the preparation as machine readable data.

23. The method of claim 22, wherein the manifest output is automatically generated based on a first selection corresponding to a premix solution and a second selection corresponding to the additive.

24. The method of claim 1, further comprising:

prompting a user to locate the receiving receptacle at the receptacle support and establish fluid interconnection between the receiving receptacle and the delivery port.

25. The method of claim 1, wherein the delivery comprises adding from about 0.1 ml of the additive to the receiving receptacle to about 750 ml of the additive to the receiving receptacle.

26. The method of claim 1, wherein the receiving step further comprises:

generating the manifest.

27. A method for use of an automatic compounder for compounding a preparation corresponding to a requested therapy to be administered to a patient, the method comprising:

receiving, at the compounder, a manifest corresponding to the preparation to be compounded, wherein the manifest comprises an indication of a receiving receptacle that contains a volume of at least a first component for inclusion in the preparation, and wherein the manifest comprises an indication of an amount of at least one additive to be added to the receiving receptacle;

establishing fluid interconnection between a delivery port of the compounder and the receiving receptacle and between an input port of the compounder and an additive receptacle containing the additive to be added to the receiving receptacle, wherein the receiving receptacle comprises a prepackaged container containing the volume of at least the first component and comprises a multichamber bag;

delivering, using a preprogrammed logic of the compounder, the amount of the additive from the additive receptacle to the receiving receptacle at least partially based on the manifest, wherein the preprogrammed logic of the compounder automatically controls flow from the input port to the delivery port; and

determining, at the compounder prior to the delivering, that the multichamber bag has been activated to establish continuous fluid communication throughout each chamber of the receiving receptacle.

28. The method of claim 27, wherein the manifest comprises an indication of an amount for each of a plurality of additives to be added to the receiving receptacle.

29. The method of claim 28, wherein the establishing further comprises establishing fluid interconnection between a plurality of additive receptacles corresponding to the plurality of additives and a plurality of respective input ports of the compounder.

30. The method of claim 29, wherein the delivering further comprises selectively controlling flow from each of said plurality of input ports and the delivery port to deliver the amount of each of the plurality of additives at least partially based on the manifest.

31. The method of claim 30, further comprising:

maintaining the fluid interconnection between the delivery port of the compounder and the receiving receptacle during the delivering of the amount of each of the plurality of additives.

32. The method of claim 31, wherein the establishing comprises a first fluid interconnection between the delivery port of the compounder and the receiving receptacle.

33. The method of claim 32, wherein the receiving receptacle comprises a premix solution comprising a parenteral nutrition (PN) solution.

34. The method of claim 29, further comprising sequencing, using the preprogrammed logic, the delivery of the plurality of additives to reduce interaction of potentially incompatible ingredients.

35. The method of claim 27, wherein the delivering is performed in an at least partially automated fashion by the compounder.

36. The method of claim 27, further comprising:

obtaining, at the compounder, information indicative of the identity of the received receiving receptacle prior to the establishing.

37. The method of claim 36, wherein the obtaining includes reading, with the compounder, a machine readable indicia corresponding to the receiving receptacle.

38. The method of claim 37, wherein the machine readable indicia comprises one of an RFID tag or a bar code physically provided with the receiving receptacle.

39. The method of claim 37, wherein the machine readable indicia corresponding to the received receiving receptacle is compared, using the preprogrammed logic, to the indication of the receiving receptacle from the manifest to verify a received receiving receptacle corresponds to the indication of the receiving receptacle.

40. The method of claim 27, wherein the receiving of the manifest comprises accepting inputs from a user by way of manual user inputs at a user interface at the compounder.

41. The method of claim 27, wherein the receiving of the manifest comprises obtaining a manifest output corresponding to the preparation as machine readable data.

42. The method of claim 41, wherein the manifest output is automatically generated based on a first selection corresponding to a premix solution and a second selection corresponding to the additive.

43. The method of claim 27, wherein the delivery comprises adding from about 0.1 ml of the additive to the receiving receptacle to about 750 ml of the additive to the receiving receptacle.

44. The method of claim 27, wherein the receiving step further comprises:

generating the manifest.