Nonsteroidal immunomodulating kit and composition and uses thereof
First Claim
Patent Images
1. A therapeutic kit comprising an aerosol packaging assembly comprising:
- a) a container accommodating a pressurized product; and
b) an outlet capable of releasing the pressurized product as a foam;
wherein the pressurized product comprises;
(A) a foamable emulsion composition comprising;
i. a nonsteroidal immunomodulating agent;
ii. at least one liquid hydrophobic carrier at a concentration of about 20% to about 50% by weight;
iii. about 0.1% to about 5% by weight of surface active agent;
iv. about 0.01% to about 5% by weight of at least one polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and
v. water; and
(B) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight;
wherein the pressurized product includes less than 5% or about 5% by weight of ethanol, propanol, isopropanol, butanol, iso-butanol, t-butanol, and pentanol, or mixtures of two or more thereof;
wherein the surface active agent comprises a non-ionic surface active agent and optionally an ionic surface active agent at a maximum amount of less than about 0.72% by weight;
wherein if ionic surfactant is present the ratio of non-ionic to ionic surface active agent is about 6;
1 or greater than 6;
1;
wherein the nonsteroidal immunomodulating agent is substantially or completely dissolved in the oil phase of the emulsion; and
wherein the pressurized product is released from the container as an expanded, breakable foam that collapses upon application of shear force.
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Accused Products
Abstract
Compositions and therapeutic kits including an aerosol container containing a foamable composition that includes a nonsteroidal immunomodulating agent are described. The foamable composition includes a liquid hydrophobic carrier; a surface-active agent; polymeric additive; water; and a propellant.
999 Citations
36 Claims
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1. A therapeutic kit comprising an aerosol packaging assembly comprising:
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a) a container accommodating a pressurized product; and b) an outlet capable of releasing the pressurized product as a foam;
wherein the pressurized product comprises;(A) a foamable emulsion composition comprising; i. a nonsteroidal immunomodulating agent; ii. at least one liquid hydrophobic carrier at a concentration of about 20% to about 50% by weight; iii. about 0.1% to about 5% by weight of surface active agent; iv. about 0.01% to about 5% by weight of at least one polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and v. water; and (B) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight; wherein the pressurized product includes less than 5% or about 5% by weight of ethanol, propanol, isopropanol, butanol, iso-butanol, t-butanol, and pentanol, or mixtures of two or more thereof; wherein the surface active agent comprises a non-ionic surface active agent and optionally an ionic surface active agent at a maximum amount of less than about 0.72% by weight; wherein if ionic surfactant is present the ratio of non-ionic to ionic surface active agent is about 6;
1 or greater than 6;
1;wherein the nonsteroidal immunomodulating agent is substantially or completely dissolved in the oil phase of the emulsion; and wherein the pressurized product is released from the container as an expanded, breakable foam that collapses upon application of shear force. - View Dependent Claims (3, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 26, 27, 28, 29, 30, 31, 35)
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2. A therapeutic foamable composition comprising:
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(a) an emulsion composition comprising; i. a nonsteroidal immunomodulating agent; ii. about 20% to about 50% by weight of a therapeutically active oil; iii. about 0.1% to about 5% by weight of surface active agent; iv. about 0.01% to about 5% by weight of at least one polymeric agent selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and v. water; and (b) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight; wherein the foamable composition includes less than 5% or about 5% by weight of ethanol, propanol, isopropanol, butanol, iso-butanol, t-butanol and pentanol or mixtures thereof; wherein the surface active agent comprises non-ionic surface active agent and optionally ionic surface active agent at a maximum amount of less than about 0.72% by weight; wherein if ionic surfactant is present the ratio of non-ionic to ionic surface active agent is about 6;
1 or greater than 6;
1;wherein the nonsteroidal immunomodulating agent is substantially or completely dissolved in the oil phase of the emulsion; and wherein upon release from a pressurized canister the foamable composition forms an expanded, breakable foam that collapses upon application of shear force. - View Dependent Claims (4, 12, 23, 24, 25, 32, 33, 34, 36)
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Specification