Sublingual apomorphine
First Claim
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1. A method of treating Parkinson'"'"'s disease in a subject in need thereof, the method comprising:
- (i) providing a pharmaceutical composition in unit dosage form that is a film having a first portion comprising apomorphine particles comprising acid addition salt of apomorphine and a second portion comprising a pH neutralizing agent, wherein the film comprises the acid addition salt of apomorphine in an amount effective to treat Parkinson'"'"'s disease; and
(ii) administering the film by placing the film sublingually in the mouth of the subject and contacting sublingual mucosal tissue with the film.
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Abstract
Disclosed are methods of treating Parkinson'"'"'s disease by (i) providing a pharmaceutical composition in unit dosage form that is a film having a first portion including apomorphine particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent, where the film contains the acid addition salt of apomorphine in an amount effective to treat Parkinson'"'"'s disease, and (ii) administering the film by placing the film sublingually in the mouth of the subject and contacting sublingual mucosal tissue with the film.
91 Citations
22 Claims
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1. A method of treating Parkinson'"'"'s disease in a subject in need thereof, the method comprising:
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(i) providing a pharmaceutical composition in unit dosage form that is a film having a first portion comprising apomorphine particles comprising acid addition salt of apomorphine and a second portion comprising a pH neutralizing agent, wherein the film comprises the acid addition salt of apomorphine in an amount effective to treat Parkinson'"'"'s disease; and (ii) administering the film by placing the film sublingually in the mouth of the subject and contacting sublingual mucosal tissue with the film. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification