Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
First Claim
1. A method for delivering nicotine to a human comprising:
- delivering the nicotine dissolved in a solvent to a skin-interface membrane of a transdermal drug delivery device coupled to skin of the human;
absorbing the nicotine from the skin-interface membrane transdermally into the human;
moving solvent from the skin-interface membrane into a solvent removal element comprising a desiccant or absorbent material of the transdermal drug delivery device; and
repeating the delivering, absorbing and moving steps to modulate and control dosing to create a plurality of nicotine blood plasma concentration peaks and troughs in the human over a 16 hour period.
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Accused Products
Abstract
Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer'"'"'s disease, sleep disorders, Parkinson'"'"'s disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body'"'"'s natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, plant extracts, botanicals, nutraceuticals, cosmeceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.
172 Citations
13 Claims
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1. A method for delivering nicotine to a human comprising:
- delivering the nicotine dissolved in a solvent to a skin-interface membrane of a transdermal drug delivery device coupled to skin of the human;
absorbing the nicotine from the skin-interface membrane transdermally into the human;
moving solvent from the skin-interface membrane into a solvent removal element comprising a desiccant or absorbent material of the transdermal drug delivery device; and
repeating the delivering, absorbing and moving steps to modulate and control dosing to create a plurality of nicotine blood plasma concentration peaks and troughs in the human over a 16 hour period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- delivering the nicotine dissolved in a solvent to a skin-interface membrane of a transdermal drug delivery device coupled to skin of the human;
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13. A method for delivering nicotine to a human comprising:
- delivering the nicotine dissolved in a solvent to a skin-interface membrane of a transdermal drug delivery device coupled to skin of the human;
absorbing the nicotine from the skin-interface membrane transdermally into the human;
moving solvent from the skin-interface membrane into a solvent removal element of the transdermal drug delivery device; and
repeating the delivering, absorbing and moving steps to modulate and control dosing to create a plurality of nicotine blood plasma concentration peaks and troughs in the human over a 16 hour period whereby permeation through the skin is assisted using one or more from the group comprising;
micro-fabricated structures, heat, sonophoresis, and a chemical permeation enhancer.
- delivering the nicotine dissolved in a solvent to a skin-interface membrane of a transdermal drug delivery device coupled to skin of the human;
Specification