Device for treating the sensory capacity of a person and method of treatment with the help of such a device

• US 9,669,239 B2
• Filed: 07/24/2012
• Issued: 06/06/2017
• Est. Priority Date: 07/27/2011
• Status: Active Grant

• Current Assignee: University Pierre et Marie Curie
• Original Assignee: University Pierre et Marie Curie
• Inventors: Carpentier, Alexandre
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): NGUYEN, HIEN NGOC
• Application Number:
  US14/234,672
• Publication Number:
  US 20140249454A1
• Time in Patent Office: 1,778 Days
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/582 Remote testing of the device
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 2007/0026 Stimulation of nerve tissue
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: H04R 2225/67 Implantable hearing aids or parts thereof not covered by H04R25/606
• CPC Class Codes: H04R 25/353 Frequency, e.g. frequency shift or compression

Abstract

A system for treating at least one sensory capacity of a person with the help of a stimulation device comprises an electronic converter of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal. The stimulation device for direct ultrasound stimulation of the sensory cortex of a brain comprises at least one support that is implantable in a skull and that includes at least one internal wall and at least one ultrasound transducer carried by the support. Means for emitting focused ultrasound waves through the internal wall of the support towards a determined zone of the sensory cortex of the patient'"'"'s brain in order to generate modulation of the brain activity in the cortex are provided. The ultrasound transducer is driven by the electronic converter to emit focused ultrasound signals that are images of the sensory signal.

Claims

1. A system for treating at least one sensory capacity of a person with a help of a stimulation device comprising an electronic converter for converting a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal, the system being characterized in that the stimulation device is a device for direct ultrasound stimulation of a sensory cortex of a patient'"'"'s brain, the ultrasound stimulation device comprising:

at least one support that is adapted to be implanted in a patient'"'"'s skull and that includes at least one internal wall; and

at least one ultrasound transducer carried by the support (2) and adapted for emitting ultrasound waves (U) through the internal wall of the support towards a determined zone of the sensory cortex of the patient'"'"'s brain in order to generate modulation of a brain activity in the cortex, the ultrasound transducer being driven by the electronic converter to emit ultrasound signals that are images of the sensory signal;

wherein the ultrasound stimulation device is provided with a flap presenting an internal face through which ultrasound waves are emitted, wherein the flap is designed to be slid between hemispheres of the patient'"'"'s brain;

wherein the flap is concave and semi-rigid and the implanted support comprises an internal face through which ultrasound waves are emitted, and the flap has ultrasound waves also emitted therethrough.

2. A treatment system according to claim 1, characterized in that the electronic converter has its input connected to at least one sensor adapted to pick up a sensory signal present in an environment of the person.

3. A treatment system according to claim 1, characterized in that the support comprises a fastener for fastening to the patient'"'"'s skull and the support having an external wall (21) connected to the internal wall via a peripheral wall.

4. A treatment system according to claim 2, characterized in that the sensor is an image acquisition system and in that the ultrasound transducer focuses the ultrasound waves towards a determined zone of a patient'"'"'s visual cerebral cortex.

5. A treatment system according to claim 1, characterized in that the internal wall of the support includes an external surface covered in a flexible material of varying thickness to provide a continuous contact interface with the brain or a dura mater and to facilitate propagation of ultrasound waves into the brain.

6. A treatment system according to claim 1, comprising an external remote control for controlling and driving the ultrasound stimulation device wirelessly.

7. A treatment system (1) according to claim 1, comprising an external control device connectable to the ultrasound stimulation device (3).

8. A treatment system according to claim 1 comprising at least one rechargeable battery arranged in the support or implanted under a skin of the patient'"'"'s body.

9. A treatment system according to claim 1, comprising electrodes on an external contact surface of the internal wall of the support for monitoring an electrical activity of the brain and for preventing any epileptic event.

10. A treatment system according to claim 1, comprising an emergency stop switch in a top wall of the support.

11. A treatment system according to claim 1, wherein the electronic converter has an input thereof connected to a system for delivering computerized sensory information that is stored in said system or that comes from a remote appliance.

16. The treatment system according to claim 1, wherein the flap has a concave shape suitable for stimulating the median visual cerebral cortex.

17. The treatment system according to claim 1, wherein the flap has ultrasound transducers mounted therein.

12. A method of treatment comprising using ultrasound waves emitted in a cranium of a patient in order to stimulate a determined zone of a sensory cortex of a patient'"'"'s brain using a treatment system, wherein the method further comprises:

forming a craniectomy hole in the patient'"'"'s cranium in register with a zone of a primary visual cortex of the brain;

opening dura mater;

sliding a flap of an ultrasound stimulation device between the brain hemispheres; and

emitting ultrasound waves through an internal face of the flap;

wherein the treatment system comprises;

an electronic converter for converting a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal, the treatment system being characterized in that the ultrasound stimulation device is a device for direct ultrasound stimulation of the sensory cortex of the patient'"'"'s brain, the ultrasound stimulation device comprising;

at least one support that is adapted to be implanted in the patient'"'"'s skull and that includes at least one internal wall; and

at least one ultrasound transducer carried by the support and adapted for emitting ultrasound waves through the internal wall of the support towards the determined zone of the sensory cortex of the patient'"'"'s brain in order to generate modulation of a brain activity in the cortex, the ultrasound transducer being driven by the electronic converter to emit ultrasound signals that are images of the sensory signal;

wherein the ultrasound stimulation device is provided with the flap presenting an internal face through which ultrasound waves are emitted, wherein the flap is designed to be slid between hemispheres of the patient'"'"'s brain and is used after the support has been mounted in the patient'"'"'s skull in register with the zone for treatment of the sensory cortex of the brain;

wherein the flap is concave and semi-rigid and the implanted support comprises an internal face through which ultrasound waves are emitted, and the flap has ultrasound waves also emitted therethrough.

13. A method of treatment according to claim 12, characterized in that a frequency of the emitted ultrasound waves lies in a frequency range 200 kHz to 10 MHz, approximately.

14. A method of treatment according to claim 12, characterized in that an electrical activity of the brain is monitored continuously in the target zone of the cortex for ultrasound emission in order to adjust the power of the transmitted ultrasound waves and to prevent any epileptic event.

15. A method of treatment according to claim 12, comprising recording reflected ultrasound waves returned by the brain so as to determine the acoustic attenuation index of the brain.