Toll like receptor modulator compounds

• US 9,670,205 B2
• Filed: 03/02/2016
• Issued: 06/06/2017
• Est. Priority Date: 03/04/2015
• Status: Active Grant

• Current Assignee: Gilead Sciences Inc.
• Original Assignee: Gilead Sciences Inc.
• Inventors: Mackman, Richard L., Zablocki, Jeff, Pyun, Hyung-jung, Aktoudianakis, Evangelos, Chin, Gregory, Metobo, Samuel E., Mish, Michael R.
• Primary Examiner(s): THOMAS, TIMOTHY P
• Application Number:
  US15/059,070
• Publication Number:
  US 20160289229A1
• Time in Patent Office: 461 Days
• CPC Class Codes: A61K 31/517 ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 239/84 Nitrogen atoms
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

Claims

1. A compound which is

3. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

2. A compound which is

4. A pharmaceutical composition comprising the compound of claim 2, and a pharmaceutically acceptable excipient.

5. A compound which is

7. A pharmaceutical composition comprising the compound of claim 5 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

6. A compound which is

8. A pharmaceutical composition comprising the compound of claim 6, and a pharmaceutically acceptable excipient.

9. A compound which is

11. A pharmaceutical composition comprising the compound of claim 9 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

10. A compound which is

12. A pharmaceutical composition comprising the compound of claim 10, and a pharmaceutically acceptable excipient.

13. A compound which is

15. A pharmaceutical composition comprising the compound of claim 13 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

14. A compound which is

16. A pharmaceutical composition comprising the compound of claim 14, and a pharmaceutically acceptable excipient.