Functionalized exendin-4 derivatives
First Claim
Patent Images
1. A peptidic compound having the formula (I):
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R1—
Z—
R2
(I),or a salt or solvate thereof,wherein Z is a peptide moiety having the formula (II);
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Abstract
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
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Citations
49 Claims
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1. A peptidic compound having the formula (I):
-
R1—
Z—
R2
(I),or a salt or solvate thereof, wherein Z is a peptide moiety having the formula (II); - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 24, 25, 26)
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22. A pharmaceutical composition comprising a peptidic compound having the formula (I):
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R1—
Z—
R2
(I),or a salt, or solvate thereof, wherein Z is a peptide moiety having the formula (II); - View Dependent Claims (23)
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27. A peptidic compound with reduced relative activity, the compound having the formula (I):
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R1—
Z—
R2
(I),or a salt, or solvate thereof, wherein Z is a peptide moiety having the formula (II); - View Dependent Claims (28, 29, 30, 31, 32, 33)
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34. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 9 or a salt or solvate thereof.
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35. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 12 or a salt or solvate thereof.
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36. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 14 or a salt or solvate thereof.
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37. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 16 or a salt or solvate thereof.
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38. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 17 or a salt or solvate thereof.
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39. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 18 or a salt or solvate thereof.
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40. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 20 or a salt or solvate thereof.
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41. A peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 21 or a salt or solvate thereof.
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42. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 9 or a salt or solvate thereof.
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43. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 12 or a salt or solvate thereof.
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44. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 14 or a salt or solvate thereof.
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45. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 16 or a salt or solvate thereof.
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46. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 17 or a salt or solvate thereof.
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47. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 18 or a salt or solvate thereof.
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48. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 20 or a salt or solvate thereof.
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49. A pharmaceutical composition comprising a peptidic compound consisting of the amino acid sequence of SEQ ID NO:
- 21 or a salt or solvate thereof.
Specification