Microarray fabrication system and method
First Claim
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1. A method for preparing a biological microarray, comprising:
- activating regions on a substrate to form a pattern of activated regions;
contacting the substrate with monomers of a self-assembling monomer solution;
polymerizing the monomers to form polymer base pads comprising a poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM) polymer only on the activated regions, wherein the polymer base pads are coupled to a molecule binding substance.
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Abstract
A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites.
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Citations
11 Claims
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1. A method for preparing a biological microarray, comprising:
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activating regions on a substrate to form a pattern of activated regions; contacting the substrate with monomers of a self-assembling monomer solution; polymerizing the monomers to form polymer base pads comprising a poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM) polymer only on the activated regions, wherein the polymer base pads are coupled to a molecule binding substance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification