System and method for measurement of vital signs of a human

• US 9,675,250 B2
• Filed: 08/26/2011
• Issued: 06/13/2017
• Est. Priority Date: 11/01/2010
• Status: Active Grant

• Current Assignee: Oxirate, Inc.
• Original Assignee: Oxirate, Inc.
• Inventors: Tverskoy, Boris
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US13/218,651
• Publication Number:
  US 20120108928A1
• Time in Patent Office: 2,118 Days
• Field of Search: 600310, 600322, 600323, 600324, 600326, 600330, 600331, 600340, 600344, 600473, 600476, 600500, 356 41
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A method and system for optical measuring one or more vital signs of a human is described. The method includes generating an optical Pulse Width Modulated (PWM) signal modulated in accordance with a predetermined Pulse Width Modulation scheme. The PWM scheme includes one or more Pulse Width Modulations having different modulation frequencies. The method also includes applying the PWM optical signal to a measurement location in a blood perfused body tissue of the human and receiving light originated back from the measurement location. A photo current signal of a time response of the blood perfused body tissue to the PWM optical signal is indicative of the vital signs. The method includes generating a voltage signal from the photo current signal and processing the voltage signal for determining the vital signs.

Claims

1. A system for optical measuring at least one vital sign of a human, the system comprising:

(a) an optical transmitter including;

an optical emitter configured for generating and applying a pulse width modulated optical signal to a measurement location in a blood perfused body tissue of the human, and

an optical signal driver including a pulse generator coupled to the optical emitter and configured for generating a series of electric pulses for driving the optical emitter by turning the optical emitter “

on”

or “

off”

, thereby to provide pulse width modulated optical signal;

wherein the optical emitter comprises at least one light source;

(b) an optical receiver including;

an optical detector configured for receiving light originated back from at least a portion of the measurement location and generating a photocurrent signal corresponding to a time response of the blood perfused body tissue to the pulse width modulated optical signal, the time response being indicative of the at least one vital sign, and

a bandwidth limiting unit coupled to the optical detector, having a predetermined gain and a predetermined bandwidth and configured for generating a voltage signal from photocurrent signal, the voltage signal being amplified to a desired gain level and having a desired band width; and

(c) a control system including;

a pulse width modulator coupled to the optical signal driver for adjusting of the width of the electric pulses transmitted to the optical signal driver that includes at least two simultaneous pulse width modulations having different modulation frequencies; and

a signal analyzer that includes a demodulator for processing the voltage signal from the optical receiver wherein the voltage signal is produced from the pulse width modulated optical signal that includes the at least two simultaneous pulse width modulations having different modulation frequencies;

wherein the control system is configured for

(i) adaptive control of the pulse width modulated optical signal emitted by the optical transmitter by adjusting at least a width of the electric pulses driving the optical emitter to maintain the optical receiver in a non-saturated dynamic range; and

(ii) processing the voltage signal generated by the bandwidth limiting unit and determining the at least one vital sign.

2. The system of claim 1, wherein the Pulse Width Modulation optical signal has a predetermined modulation frequency.

3. The system of claim 1, wherein the Pulse Width Modulation optical signal has three different modulation frequencies.

4. The system of claim 1, wherein the series of electric pulses after the at least two Pulse Width Modulations comprises repetitive bursts of electric pulse samples, each burst having a predetermined burst duration time and a predetermined burst duty cycle, and each burst comprising a predetermined number of electric pulse samples having a predetermined sample width and a predetermined sample duty cycle.

5. The system of claim 3, wherein the series of electric pulses after the three Pulse Width Modulations comprises repetitive trains of bursts of electric pulse samples, each train of the bursts has a predetermined train duration time and train duty cycle and comprises a predetermined number of bursts having a predetermined burst duration time and a predetermined burst duty cycle, and each burst comprising a predetermined number of electric pulse samples having a predetermined sample width and a predetermined sample duty cycle.

6. The system of claim 1, wherein the at least one light source operates at a wavelength in the range of 620 nm-1000 nm.

7. The system of claim 1, wherein the optical transmitter comprises a plurality of optical emitters activated either simultaneously or consequently.

8. The system of claim 1, wherein the optical detector comprises at least one photodiode.

9. The system of claim 1, wherein the bandwidth limiting unit has a bandwidth with a corner frequency below the highest Pulse Width Modulation frequency.

10. The system of claim 1, wherein the bandwidth limiting unit includes a transimpedance amplifier configured for amplifying and low pass filtering the photocurrent signal.

11. The system of claim 10, wherein the transimpedance amplifier includes an operational amplifier.

12. The system of claim 10, wherein the bandwidth limiting unit includes an additional low pass filter arranged downstream and coupled to the transimpedance amplifier.

13. The system of claim 12, wherein a cut-off frequency of the additional low pass filter is positioned between a frequency of the variation of the measured vital sign and a highest frequency of the Pulse Width Modulator.

14. The system of claim 10, wherein the bandwidth limiting unit includes a band pass filter arranged downstream and coupled to the transimpedance amplifier.

15. The system of claim 14, wherein the band pass filter has a center frequency equal to a second frequency of the at least two Pulse Width Modulations that is lower than the highest frequency.

16. The system of claim 1, wherein the signal analyzer includes a demodulator configured for processing the voltage signal generated by the bandwidth limiting unit for determining the at least one vital sign.

17. The system of claim 16, wherein the demodulator is a digital demodulator including A/D converter configured for converting the voltage signal generated by the bandwidth limiting unit from an analog form to a digital sampled form.

18. The system of claim 16, wherein the demodulator is an analog demodulator.

19. The system of claim 1, wherein the control unit comprises a feedback controller coupled to the bandwidth limiting unit and to the Pulse Width Modulator.

20. The system of claim 19, wherein the feedback controller is (i) responsive to changes in a signal amplitude at an output of an amplifier of the bandwidth limiting unit, and (ii) configured to generate an amplifier gain control signal configured for controlling operation of the Pulse Width Modulator by adjusting at least the width of the electric pulses to maintain a gain level obtained at the output of the amplifier within an optimal range for operation of the amplifier.

21. The system of claim 19, wherein the feedback controller is (i) responsive to changes in a signal amplitude at an output of a band pass filter of the bandwidth limiting unit, and (ii) configured to generate a filter control signal configured for controlling operation of the Pulse Width Modulator by adjusting the width of the electric pulses to maintain the signal amplitude at the output of the band pass filter within an optimal range for operation of the band pass filter.

22. The system of claim 19, wherein the feedback controller is (i) responsive to changes of at least one modulation frequency of the Pulse Width Modulated optical output at an output of at least one unit of the bandwidth limiting unit selected from an amplifier, a low pass filter and a band pass filter;

and (ii) configured to generate frequency control signals in order to match the frequency characteristics of the amplifier, the low pass filter and/or the band pass filter.

23. The system of claim 19, wherein the feedback controller is (i) responsive to changes in a signal amplitude at an input of the demodulator, and (ii) configured to generate a detector control signal configured for controlling operation of the Pulse Width Modulator by adjusting the width of the electric pulses to maintain the demodulator within an optimal dynamic range for operation of the demodulator.

24. The system of claim 5, comprising a feedback controller coupled to the bandwidth limiting unit and to the Pulse Width Modulator, wherein the feedback controller is (i) responsive to the time response of the blood perfused body tissue to the optical signal, and (ii) configured to generate a measurement time interval control signal in order to adjust at least one modulation parameter selected from the train duration time and the train duty cycle to the variations of a heart rate of the human.

25. The system of claim 1, wherein the at least one vital sign of the human is selected from the list including a heart rate, a heart rate variability, an oxygen saturation, and a total blood hemoglobin.

26. A method for optical measuring at least one vital sign of a human, the method comprising:

generating a Pulse Width Modulated (PWM) optical signal that includes at least two simultaneous pulse width modulations having different modulation frequencies and, adjusting at least a pulse width of the PWM optical signal;

applying the PWM optical signal to a measurement location in a blood perfused body tissue of the human;

receiving light originated back from at least a portion of the measurement location and generating a photo current signal corresponding to a time response of the blood perfused body tissue to the PWM optical signal, the time response being indicative of the at least one vital sign;

generating a voltage signal from the photo current signal;

processing the voltage signal by demodulating the voltage signal produced from the PWM optical signal that includes the at least two simultaneous pulse width modulations having different modulation frequencies; and

determining the at least one vital sign from the voltage signal after demodulation.

27. The method of claim 26, wherein the Pulse Width Modulated optical output includes three Pulse Width Modulations having three different modulation frequencies.

28. The method of claim 26, wherein the generating of the voltage signal includes amplifying the voltage signal to a desired gain level and filtering the voltage signal to a desired band width.

29. The method of claim 26, wherein the processing of the voltage signal includes:

converting the voltage signal from an analog form to a digital sampled form;

for several periods of the Pulse Width Modulation having a lower modulation frequency than the highest modulation frequency, calculating root mean square values of measured amplitudes of samples of the sampled voltage signal located in each period of the Pulse Width Modulation having the highest modulation frequency;

executing a discrete Fourier transform of the root mean square values over the several periods; and

determining a major harmonic of the variations of the root mean square values.

30. The method of claim 29, wherein the processing is carried out for a measurement at a wavelength corresponding to the red to near infrared spectral range, thereby obtaining a heart rate of the human indicated by the major harmonic.

31. The method of claim 29, wherein the processing is carried out for a measurement at two different wavelengths in the red band of light and in the infrared band of light, correspondingly.

32. The method of claim 31, comprising calculating a ratio of predetermined functions of the magnitudes of the major Fourier component of the root mean square values over the several periods for the two various wavelengths, thereby obtaining a blood oxygen saturation rate of the human.

33. The method of claim 27, wherein the generating of the optical Pulse Width Modulated (PWM) signal is carried out only during measurements intervals defined by the lowest modulation frequency of the three Pulse Width Modulations.

34. The method of claim 27, comprising adjusting at least a duty cycle of at least one modulation of the at least three Pulse Width Modulations.

35. The method of claim 34, comprising providing a feedback closed loop control configured for the adjusting of the duty cycle of the at least one modulation of the at least three Pulse Width Modulations.