Impedance devices and methods to use the same to obtain luminal organ measurements

• US 9,675,257 B2
• Filed: 03/16/2014
• Issued: 06/13/2017
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: 3DT Holdings LLC
• Original Assignee: 3DT Holdings LLC
• Inventors: Kassab, Ghassan S.
• Primary Examiner(s): EISEMAN, ADAM JARED
• Application Number:
  US14/215,013
• Publication Number:
  US 20140276191A1
• Time in Patent Office: 1,185 Days
• Field of Search: 600547, 600506, 600505, 600587, 600481, 600486, 600454, 600561, 606192, 606194, 606198, 606 33, 606 41, 128898, 424439, 623 111, 623 115, 623 237
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/027 using catheters
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter

Abstract

Impedance devices and methods to use the same to obtain luminal organ measurements. In at least one embodiment of an impedance device of the present disclosure, the impedance device comprises an elongated body having a distal body end, and a first electrode located along the elongated body at or near the distal body end, the first electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, wherein a measured parameter of the mammalian luminal organ can be calculated based in part upon the one or more conductance values obtained by the first electrode.

Claims

1. An impedance system, comprising:

an impedance device comprising;

an elongated body having a distal body end;

a first electrode located along the elongated body at the distal body end, wherein the first electrode is configured to obtain one or more conductance values within a mammalian luminal organ within an electric field and to operate as an excitation electrode and a detection electrode; and

a second electrode positioned along the elongated body;

a first external electrode for placement upon or within a mammalian body, the first external electrode not coupled to the elongated body; and

a second external electrode for placement upon or within a mammalian body, the second external electrode not coupled to the elongated body;

wherein the first electrode is configured to generate the electric field within a mammalian body when the first external electrode is positioned upon or within the mammalian body and when the first electrode and the first external electrode are activated;

wherein the second electrode and the second external electrode are configured to detect the electric field generated by the first electrode and the first external electrode when the second external electrode is positioned upon or within the mammalian body; and

wherein a measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement can be calculated based in part upon the one or more conductance values obtained by the first electrode.

2. The impedance system of claim 1, wherein a known distance between the first electrode and the second electrode is between 0.5 mm and 1 mm, inclusive.

3. The impedance system of claim 1, wherein the impedance device further comprises:

a third electrode positioned along the elongated body, the third electrode also configured to detect the electric field generated by the first electrode and the first external electrode.

4. The impedance system of claim 1, wherein the elongated body is selected from the group consisting of an elongated wire and an elongated catheter.

5. The impedance system of claim 1, further comprising:

a pressure sensor configured to detect a pressure within the mammalian luminal organ when at least part of the impedance device is positioned therein.

6. The impedance system of claim 1, further comprising:

a temperature sensor configured to detect a temperature within the mammalian luminal organ when at least part of the impedance device is positioned therein.

7. The impedance system of claim 1, further comprising:

an ablation contact configured to ablate within the mammalian luminal organ when at least part of the impedance device is positioned therein.

8. The impedance system of claim 1, wherein the elongated body is configured as a catheter, and whereby the elongated body further defines a suction/infusion port in communication with a lumen of the elongated body configured so that a fluid can be injected through the lumen and out of the suction/infusion port.

9. A method of using an impedance device, the method comprising the steps of:

introducing at least part of an impedance device into a mammalian luminal organ at a first location, the impedance device comprising;

an elongated body having a distal body end, and

a first electrode and a second electrode each located along the elongated body at the distal body end, the first electrode and the second electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, and wherein the first electrode is configured to operate as an excitation electrode and a detection electrode;

providing electrical current to the first electrode and a first external electrode not coupled to the elongated body to generate the electric field, the first external electrode positioned upon or within a mammalian body having the mammalian luminal organ;

obtaining at least one conductance value using the impedance device within the electric field; and

calculating a measured parameter of the mammalian luminal organ based in part upon the at least one conductance value, the measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement.

10. The method of claim 9, wherein the measured parameter is selected from the group consisting of a luminal organ diameter and a luminal organ cross-sectional area, and wherein the step of obtaining is performed in the presence of a bolus of an injected fluid having a known conductivity different than that of blood.

11. The method of claim 9, wherein the impedance device further comprises a third electrode positioned along the elongated body, and wherein the step of obtaining the at least one conductance value is performed using the third electrode.

12. The method of claim 9, wherein the step of obtaining is performed when the first electrode is at a first location within the mammalian luminal organ, and wherein the method further comprises the following steps to be performed after the step of obtaining the at least one conductance value:

moving the first electrode of the impedance device to a second location within the mammalian luminal organ;

obtaining at least another conductance value using the impedance device within a field selected from the group consisting of the electric field and a second electric field; and

calculating a second measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement based in part upon the at least another conductance value.

13. The method of claim 12, wherein the method further comprises the following steps to be performed after the step of obtaining the at least another conductance value:

moving the first electrode of the impedance device to a third location within the mammalian luminal organ; and

obtaining at least an additional conductance value using the impedance device within a field selected from the group consisting of the electric field, the second electric field, and a third electric field;

calculating a third measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement based in part upon the at least an additional conductance value; and

constructing an additional profile of the mammalian luminal organ based in part upon the measured parameter, the second measured parameter, and the third measured parameter.

14. The method of claim 9, further comprising the step of:

constructing a profile of the mammalian luminal organ based in part upon the measured parameter and the second measured parameter.

15. The method of claim 9, further comprising the steps of:

inflating a balloon coupled to the impedance device to breakup materials causing a stenosis within the mammalian luminal organ; and

implanting a stent into the mammalian luminal organ by inflating the balloon.

16. The method of claim 9, further comprising the step of:

measuring a velocity of fluid flow through the mammalian luminal organ using the impedance device.

17. A method of using an impedance device, the method comprising the steps of:

introducing at least part of an impedance device into a mammalian luminal organ at a first location, the impedance device comprising;

an elongated body having a distal body end, and

a first electrode and a second electrode each located along the elongated body at the distal body end, the first electrode and the second electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, and wherein the first electrode is configured to operate as an excitation electrode and a detection electrode;

providing electrical current to the first electrode and a first external electrode not coupled to the elongated body to generate the electric field, the first external electrode positioned upon or within a mammalian body having the mammalian luminal organ;

obtaining at least one conductance value using the impedance device within the electric field and within an undiluted bolus of an injected first solution having a known conductivity differing from a blood conductivity; and

calculating a measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement based in part upon the at least one conductance value.

18. The method of claim 17, wherein the impedance device further comprises a third electrode positioned along the elongated body, and wherein the step of obtaining the at least one conductance value is performed using the third electrode.

19. The method of claim 17, wherein the step of obtaining is performed when the first electrode is at a first location within the mammalian luminal organ, and wherein the method further comprises the following steps to be performed after the step of obtaining the at least one conductance value:

moving the first electrode of the impedance device to a second location within the mammalian luminal organ;

obtaining at least another conductance value using the impedance device within a field selected from the group consisting of the electric field and a second electric field, the step of obtaining the at least another conductance value also performed within a bolus selected from the undiluted bolus of the injected first solution and an undiluted bolus of an injected second solution having a known conductivity differing from the blood conductivity;

calculating a second measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement based in part upon the at least another conductance value; and

constructing a profile of the mammalian luminal organ based in part upon the measured parameter and the second measured parameter.

20. The method of claim 19, wherein the method further comprises the following steps to be performed after the step of obtaining the at least another conductance value:

moving the first electrode of the impedance device to a third location within the mammalian luminal organ; and

obtaining at least an additional conductance value using the impedance device within a field selected from the group consisting of the electric field, the second electric field, and a third electric field;

calculating a third measured parameter of the mammalian luminal organ calculatable from at least one conductivity measurement based in part upon the at least an additional conductance value; and

constructing an additional profile of the mammalian luminal organ based in part upon the measured parameter, the second measured parameter, and the third measured parameter.