Pulsatile venous blood stoppage for analyte detection
First Claim
1. A wearable device, comprising:
- a mount for attaching the wearable device to an external body surface proximate to a vessel having a fluid flowing therethrough;
a downstream clamp, positioned on the mount, that is configured to apply a downward force to the vessel sufficient to inhibit a flow of the fluid through the vessel beyond the downstream clamp, with respect to a direction of fluid flow through the vessel;
an upstream clamp, positioned on the mount upstream of the downstream clamp, that is configured to apply a downward force to the vessel sufficient to inhibit a flow of fluid through the vessel beyond the upstream clamp, with respect to the direction of fluid flow through the vessel; and
a detector, positioned between the downstream clamp and the upstream clamp, that can detect a response signal transmitted from a probe region of the vessel, wherein the probe region is positioned between the downstream clamp and the upstream clamp, and wherein the response signal is indicative of one or more target analytes in the vessel.
4 Assignments
0 Petitions
Accused Products
Abstract
A wearable device includes a mount configured to mount the wearable device to an external body surface proximate to a vessel, a downstream clamp configured to apply a force to the vessel sufficient to inhibit a flow of fluid through the vessel beyond the downstream clamp, and an upstream clamp, positioned upstream of the downstream clamp, configured to apply a force to the vessel sufficient to accelerate a volume of fluid in a downstream direction with respect to a direction of fluid flow through the vessel. A detector may also be provided for detecting a response signal transmitted from a probe region of the vessel positioned upstream of the first clamp. The response signal is related to the presence or absence of one or more target analytes in the vessel.
16 Citations
24 Claims
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1. A wearable device, comprising:
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a mount for attaching the wearable device to an external body surface proximate to a vessel having a fluid flowing therethrough; a downstream clamp, positioned on the mount, that is configured to apply a downward force to the vessel sufficient to inhibit a flow of the fluid through the vessel beyond the downstream clamp, with respect to a direction of fluid flow through the vessel; an upstream clamp, positioned on the mount upstream of the downstream clamp, that is configured to apply a downward force to the vessel sufficient to inhibit a flow of fluid through the vessel beyond the upstream clamp, with respect to the direction of fluid flow through the vessel; and a detector, positioned between the downstream clamp and the upstream clamp, that can detect a response signal transmitted from a probe region of the vessel, wherein the probe region is positioned between the downstream clamp and the upstream clamp, and wherein the response signal is indicative of one or more target analytes in the vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method, comprising:
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applying, during a probe time, a force to a vessel with a first clamp sufficient to inhibit a flow of fluid through the vessel beyond the first clamp; detecting, with a detector, a response signal transmitted from a probe region of the vessel during the probe time, wherein the probe region is positioned upstream of the first clamp with respect to a direction of fluid flow through the vessel, and wherein the response signal is indicative of one or more target analytes in the vessel; after the probe time, while maintaining the force applied to the vessel by the first clamp, applying a force to the vessel with a second clamp sufficient to inhibit a flow of fluid through the vessel beyond the second clamp, wherein the second clamp is positioned upstream of the first clamp with respect to the direction of fluid flow in the vessel; and after applying the force to the vessel with the second clamp, releasing the force applied to the vessel by the first clamp; wherein the detector is positioned between the first clamp and the second clamp. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. A method, comprising:
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during each of a plurality of probe times, applying a force to a vessel with a first clamp sufficient to inhibit a flow of fluid through the vessel beyond the first clamp; during each of the plurality of probe times, detecting with a detector a response signal transmitted from a probe region of the vessel, wherein the probe region is positioned upstream of the first clamp with respect to a direction of fluid flow through the vessel, and wherein the response signal is related to one or more target analytes in the vessel; and after each of the plurality of probe times, while maintaining the force applied to the vessel by the first clamp, applying a force to the vessel with a second clamp sufficient to accelerate a volume of fluid in a downstream direction with respect to a direction of fluid flow through the vessel, wherein the second clamp is positioned upstream of the first clamp with respect to the direction of fluid flow in the vessel; wherein the detector is positioned between the first clamp and the second clamp. - View Dependent Claims (19, 20, 21, 22, 23, 24)
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Specification