Ablation device with guide sleeves

• US 9,675,406 B2
• Filed: 02/15/2011
• Issued: 06/13/2017
• Est. Priority Date: 02/16/2010
• Status: Active Grant

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Avuthu, Sravanthi, Pearson, Robert M., Moss, Kevin Lee, Moshe, Meir Hai
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): Zink, Amanda
• Application Number:
  US13/027,801
• Publication Number:
  US 20110202053A1
• Time in Patent Office: 2,310 Days
• Field of Search: 606 32- 45
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2018/00613 Irreversible electroporation reversible electroporation A61N1/327
• CPC Class Codes: A61B 2018/124 switching the output to different electrodes, e.g. sequentially
• CPC Class Codes: A61B 2018/143 multiple needles
• CPC Class Codes: A61B 2018/1432 curved
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing

Abstract

An energy delivery device for treating a patient includes a probe body; a plurality of guide sleeves positioned inside the probe body and adapted to be deployed radially away from the probe body and into tissue of the patient; and a plurality of elongate electrode elements each adapted to receive electrical treatment energy from an energy source and adapted to be deployed into the tissue through a corresponding deployed guide sleeve. The guide sleeves provide a structural pathway for guiding the electrodes along their intended trajectory and for determining the angle of deployment of the electrodes relative to the longitudinal axis of the probe body.

Claims

1. An energy delivery device for treating a patient by electroporation (EP) comprising:

a probe body having a plurality of circumferentially arranged openings at a predetermined distance from a distal end of the probe body;

at least three guide sleeves positioned inside the probe body and adapted to be deployed outside of the probe body through a respective opening and into tissue of the patient, the at least three guide sleeves being adapted to deploy at predetermined circumferential angles and uniformly spaced relative to each other such that the circumferential angle between any two of the at least three adjacent deployed guide sleeves is substantially the same; and

a plurality of elongate electrode elements, each having an outer layer comprised of an insulative material, each elongate electrode element adapted to receive EP pulses as electrical treatment energy from an energy source and adapted to be deployed into the tissue through a corresponding deployed guide sleeve.

2. The energy delivery device of claim 1, wherein the at least three guide sleeves are pre-curved guide sleeves wherein the extent of sleeve deployment determines the angle of deployment for the corresponding elongate electrode element relative to the longitudinal axis of the probe body and the extent of guide sleeve deployment is selectable by a user.

3. The energy delivery device of claim 2, wherein each pre-curved guide sleeve has a proximal curved portion and a distal straight portion.

4. The energy delivery device of claim 2, wherein each pre-curved guide sleeve is sufficiently curved to allow the corresponding elongate electrode element to be deployed at an angle greater than 90 degrees relative to the longitudinal axis of the probe body.

5. The energy delivery device of claim 1, wherein each of the at least three guide sleeves includes an electrode area adapted to deliver the electrical treatment energy to the tissue.

6. The energy delivery device of claim 1, wherein a distal portion of the probe body includes an electrode area adapted to deliver the electrical treatment energy to the tissue.

7. The energy delivery device of claim 1, wherein an area proximal to the location where the guide sleeves exit the probe body includes an electrode area adapted to deliver the electrical treatment energy to the tissue.

8. The energy delivery device of claim 1, further comprising an introducer sheath through which the probe body is inserted and including an electrode area adapted to deliver the electrical treatment energy to the tissue.

9. The energy delivery device of claim 1, further comprising:

a shaft disposed inside the probe body;

a probe tip attached to the shaft for movement between an open position in which a distal portion of the probe body is longitudinally spaced from a proximal portion of the probe tip, and a closed position in which the distal portion of the probe body slides over the proximal portion of the probe tip to provide structural strength during insertion of the probe body into the tissue.

10. A method of treating a patient by electroporation (EP) comprising:

inserting a probe body of an energy delivery device into tissue of the patient, the probe body having a plurality of circumferentially arranged openings at a predetermined distance from a distal end of the probe body;

deploying at least three guide sleeves positioned inside the probe body outside of the probe body through a respective opening and into the tissue, the at least three guide sleeves being adapted to deploy at predetermined circumferential angles and uniformly spaced relative to each other such that the circumferential angle between any two of the at least three adjacent deployed guide sleeves is substantially the same;

deploying a plurality of elongate electrode elements through the at least three deployed guide sleeves using the at least three deployed guide sleeves as a guide, each of the plurality of elongate electrode elements having an insulation layer adapted to be deployed through the guide sleeves; and

delivering EP pulses as electrical treatment energy to the tissue through the deployed electrodes.

11. The method of claim 10, wherein the at least three guide sleeves are pre-curved and the step of deploying the at least three guide sleeves includes deploying the at least three guide sleeves for a selected amount to establish the angle of deployment for the elongate electrode elements relative to the longitudinal axis of the probe body.

12. The method of claim 10, prior to the step of inserting a probe body, further comprising:

inserting, into the tissue, an introducer sheath having an electrode area adapted to deliver the electrical treatment energy to the tissue.

13. The method of claim 12, wherein the introducer sheath includes a proximal electrical connector coupled to the electrode area and the method further comprises connecting the proximal electrical connector to an electrical connection located on the probe body.

14. The method of claim 10, wherein the energy delivery device includes:

a shaft disposed inside the probe body; and

a probe tip attached to the shaft for movement between an open position in which a distal portion of the probe body is longitudinally spaced from a proximal portion of the probe tip, and a closed position in which the distal portion of the probe body slides over the proximal portion of the probe tip, wherein;

the step of inserting a probe body includes;

inserting the probe body with the probe tip in the closed position;

moving the probe tip to the open position for deployment of the plurality of elongate electrode elements.