Methods and apparatus for renal neuromodulation
First Claim
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1. A method for treatment of a human patient diagnosed with hypertension, the method comprising:
- intravascularly positioning a catheter in a reduced profile delivery configuration within a renal blood vessel and at least partially adjacent to renal nerves of the patient;
transforming a distal basket of the catheter from the delivery configuration to a treatment configuration, wherein, in the treatment configuration, the distal basket is expanded to place a plurality of electrodes arranged thereabout into contact with an inner wall of the renal blood vessel of the patient;
selectively energizing a first bipolar electrode pair carried by a first strut of the basket and delivering a first bipolar energy field to the renal nerves; and
selectively energizing a second bipolar electrode pair carried by a second, different strut of the basket and delivering a second bipolar energy field to the renal nerves,wherein delivering the first and second bipolar energy fields modulates neural function of the renal nerves.
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Abstract
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
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Citations
22 Claims
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1. A method for treatment of a human patient diagnosed with hypertension, the method comprising:
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intravascularly positioning a catheter in a reduced profile delivery configuration within a renal blood vessel and at least partially adjacent to renal nerves of the patient; transforming a distal basket of the catheter from the delivery configuration to a treatment configuration, wherein, in the treatment configuration, the distal basket is expanded to place a plurality of electrodes arranged thereabout into contact with an inner wall of the renal blood vessel of the patient; selectively energizing a first bipolar electrode pair carried by a first strut of the basket and delivering a first bipolar energy field to the renal nerves; and selectively energizing a second bipolar electrode pair carried by a second, different strut of the basket and delivering a second bipolar energy field to the renal nerves, wherein delivering the first and second bipolar energy fields modulates neural function of the renal nerves. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for renal neuromodulation, the method comprising:
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transluminally positioning an expandable basket of a renal denervation catheter at an intravascular location within a renal artery of a human patient and adjacent to neural fibers innervating a kidney of the patient; transforming the expandable basket from a low-profile delivery configuration to an expanded treatment configuration, wherein, in the treatment configuration, the basket is sized and shaped to place a first bipolar electrode pair carried by a first strut of the basket and a second bipolar electrode pair carried by a second, different strut of the basket in apposition with target tissue at or near the neural fibers; and ablating the neural fibers innervating the kidney via radio frequency (RF) energy from the first and second bipolar electrode pairs. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification