Injectable cryogel vaccine devices and methods of use thereof
First Claim
Patent Images
1. An injectable device comprising a cell-adhesive, highly crosslinked cryogel composition comprising open interconnected macropores,wherein said cryogel composition comprises at least 75% pores,wherein said cryogel composition is characterized by shape memory following deformation by compression through a needle,wherein said cryogel composition comprises a crosslinked gelatin polymer, wherein said gelatin is methacrylated,wherein said cryogel composition comprises a methacrylated gelatin concentration of 0.5% to 1.4% (w/v), andwherein said cryogel composition comprises a live attenuated breast cancer cell in one or more of said open interconnected pores.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides polymer compositions for cell and drug delivery.
-
Citations
39 Claims
-
1. An injectable device comprising a cell-adhesive, highly crosslinked cryogel composition comprising open interconnected macropores,
wherein said cryogel composition comprises at least 75% pores, wherein said cryogel composition is characterized by shape memory following deformation by compression through a needle, wherein said cryogel composition comprises a crosslinked gelatin polymer, wherein said gelatin is methacrylated, wherein said cryogel composition comprises a methacrylated gelatin concentration of 0.5% to 1.4% (w/v), and wherein said cryogel composition comprises a live attenuated breast cancer cell in one or more of said open interconnected pores.
-
25. A syringe comprising an injectable device comprising a cell-adhesive, highly crosslinked cryogel composition comprising open interconnected pores,
wherein said cryogel composition comprises at least 75% pores, wherein said cryogel composition is characterized by shape memory following deformation by compression, wherein said cryogel composition comprises a crosslinked gelatin polymer, wherein said gelatin is methacrylated, wherein said cryogel composition comprises a methacrylated gelatin concentration of 0.5% to 1.4% (w/v), and wherein said cryogel composition comprises live attenuated breast cancer cells in one or more of said open interconnected pores.
-
35. An injectable device comprising a cell-adhesive, highly crosslinked cryogel composition comprising open interconnected macropores,
wherein said cryogel composition comprises at least 75% pores, wherein said cryogel composition is characterized by shape memory following deformation by compression through a needle, wherein said cryogel composition comprises a crosslinked gelatin polymer, wherein said gelatin is methacrylated, and wherein said cryogel composition comprises a methacrylated gelatin concentration of 0.5% to 1.4% (w/v).
Specification