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Injectable cryogel vaccine devices and methods of use thereof

  • US 9,675,561 B2
  • Filed: 01/28/2014
  • Issued: 06/13/2017
  • Est. Priority Date: 04/28/2011
  • Status: Active Grant
First Claim
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1. An injectable device comprising a cell-adhesive, highly crosslinked cryogel composition comprising open interconnected macropores,wherein said cryogel composition comprises at least 75% pores,wherein said cryogel composition is characterized by shape memory following deformation by compression through a needle,wherein said cryogel composition comprises a crosslinked gelatin polymer, wherein said gelatin is methacrylated,wherein said cryogel composition comprises a methacrylated gelatin concentration of 0.5% to 1.4% (w/v), andwherein said cryogel composition comprises a live attenuated breast cancer cell in one or more of said open interconnected pores.

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