Dosing regimens for treating and/or preventing cerebral amyloidoses
First Claim
Patent Images
1. A method for treating Alzheimer'"'"'s disease or cerebral amyloid angiopathy in a patient diagnosed with the same, the method comprising:
- administering daily to the patient an effective amount of 2-acetamido-1,2-dideoxynojirimycin (AdDNJ) for a first enzyme enhancement period of about 1 day to about 8 days;
not administering the AdDNJ for a substrate turnover period of about 48 hours to about 96 hours; and
thenadministering to the patient an effective amount of AdDNJ for a second enzyme enhancement period of about 1 day to about 8 days.
3 Assignments
0 Petitions
Accused Products
Abstract
Described herein are dosing regimens and kits for the treatment and/or prevention of cerebral amyloidoses such as Alzheimer'"'"'s disease (AD) and/or cerebral amyloid angiopathy (CAA).
4 Citations
16 Claims
-
1. A method for treating Alzheimer'"'"'s disease or cerebral amyloid angiopathy in a patient diagnosed with the same, the method comprising:
-
administering daily to the patient an effective amount of 2-acetamido-1,2-dideoxynojirimycin (AdDNJ) for a first enzyme enhancement period of about 1 day to about 8 days; not administering the AdDNJ for a substrate turnover period of about 48 hours to about 96 hours; and
thenadministering to the patient an effective amount of AdDNJ for a second enzyme enhancement period of about 1 day to about 8 days. - View Dependent Claims (2, 3, 4, 5, 6, 7, 10, 11, 12, 13, 14, 15)
-
-
8. A method for treating Alzheimer'"'"'s disease or cerebral amyloid angiopathy in a patient diagnosed with the same, the method comprising:
-
administering daily to the patient an effective amount of 2-acetamido-1,2-dideoxynojirimycin (AdDNJ) for a first enzyme enhancement period of about 5 days; not administering the AdDNJ for a substrate turnover period of about 72 hours; and
thenadministering to the patient an effective amount of AdDNJ for a second enzyme enhancement period of about 1 day to about 8 days.
-
-
9. A method for treating Alzheimer'"'"'s disease or cerebral amyloid angiopathy in a patient diagnosed with the same wherein the method comprises:
-
administering to the patient an effective amount of AdDNJ on a first day; not administering the AdDNJ on a second day; administering to the patient an effective amount of AdDNJ on a third day; not administering the AdDNJ on a fourth day; administering to the patient an effective amount of AdDNJ on a fifth day; and
thennot administering the AdDNJ for a period of about 72 hours.
-
-
16. A kit comprising:
-
one or more active dosage forms comprising an effective amount of 2-acetamido-1,2-dideoxynojirimycin (AdDNJ); one or more inactive dosage forms that do not comprise an effective amount of AdDNJ; and instructions for; administering the dosage forms for a first enzyme enhancement period of about 1 day to about 8 days; not administering the dosage forms for a substrate turnover period of about 48 hours to about 96 hours; and
thenadministering the dosage forms for a second enzyme enhancement period of about 1 day to about 8 days.
-
Specification