Topical tetracycline compositions
DCFirst Claim
1. A waterless composition comprisinga tetracycline antibiotic and a carrier, the carrier comprising:
- a) at least one hydrophobic oil; and
b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a wax comprising a hydrogenated oil;
or (v) a combination of two or more waxes;
wherein the composition does not contain one or more minocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, isostearic acid, and ethocel;
and wherein the composition does not contain a polyol and/or polyethylene glycol.
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Abstract
A topical therapeutic hydrophobic breakable composition includes a carrier comprising, (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
985 Citations
62 Claims
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1. A waterless composition comprising
a tetracycline antibiotic and a carrier, the carrier comprising: -
a) at least one hydrophobic oil; and b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a wax comprising a hydrogenated oil;
or (v) a combination of two or more waxes;wherein the composition does not contain one or more minocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, isostearic acid, and ethocel; and wherein the composition does not contain a polyol and/or polyethylene glycol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 59, 60, 61, 62)
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57. A waterless composition comprising a tetracycline antibiotic and a carrier, the carrier comprising:
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a) at least one hydrophobic oil; and b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a gelled mineral oil;
(v) a wax comprising a hydrogenated oil;
or (vi) a combination of two or more waxes;wherein the composition does not contain a polyol and/or polyethylene glycol. - View Dependent Claims (58)
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Specification