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Mucus penetrating gene carriers

  • US 9,675,711 B2
  • Filed: 05/02/2016
  • Issued: 06/13/2017
  • Est. Priority Date: 02/08/2011
  • Status: Active Grant
First Claim
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1. A method of delivering a nucleic acid across a mucosal surface, the method comprising administering an effective amount of a composition comprising nucleic acid nanoparticles, the nucleic acid nanoparticles comprising:

  • a) a complex formed by the ionic association of one or more nucleic acids and one or more polycationic polymers, andb) one or more mucus-resistant/diffusive graft co-polymers non-covalently associated to the complex,wherein the nucleic acid nanoparticles have an average diameter of between 5 and 500 nm,wherein the one or more mucus-resistant/diffusive graft co-polymers comprise a polycationic polymer backbone having multiple mucus-resistant/diffusive polymer side chains covalently attached thereto,wherein the ratio of mucus-resistant/diffusive polymer side chains to the polycationic backbone is between 15;

    1 and 60;

    1, or wherein the one or more polycationic polymers and one or more mucus-resistant/diffusive graft co-polymers are present in a molar ratio of between 1;

    5 and 5;

    1; and

    wherein the nanoparticles have a near neutral surface charge between about −

    10 mV and about +10 mV.

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