Catheters having an antimicrobial treatment

• US 9,675,735 B2
• Filed: 08/20/2015
• Issued: 06/13/2017
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Parasol Medical LLC
• Original Assignee: Parasol Medical LLC
• Inventors: Eddy, Patrick E.
• Primary Examiner(s): Sasan, Aradhana
• Application Number:
  US14/831,243
• Publication Number:
  US 20150352320A1
• Time in Patent Office: 663 Days
• CPC Class Codes: A61L 2300/208 Quaternary ammonium compounds
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 1/285 Catheters therefor
• CPC Class Codes: A61M 1/3661 for haemodialysis
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 2025/006 having a special surface topography or special surface properties, e.g. roughened or knurled surface
• CPC Class Codes: A61M 2039/267 having a sealing sleeve around a tubular or solid stem portion of the connector
• CPC Class Codes: A61M 2202/0021 removed from and reintroduced into the body, e.g. after treatment
• CPC Class Codes: A61M 2202/0413 Blood
• CPC Class Codes: A61M 2205/0205 Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
• CPC Class Codes: A61M 2210/12 Blood circulatory system
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 39/26 Valves closing automatically on disconnecting the line and opening on reconnection thereof check valves A61M39/24
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A vascular access product is provided having a component with a plurality of external surfaces. At least one of the surfaces is coated with an antimicrobial treatment, wherein the antimicrobial material comprises a silane quaternary ammonium salt. The silane quaternary ammonium salt may comprise 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride. The vascular access product may be IV administration tubing, a catheter and the associated caps, luers, Y sites, connectors, drip chambers, PICC lines, stopcocks and similar IV components such as needleless IV connectors having valve mechanisms.

Claims

1. A vascular access product comprising:

a component having a plurality of external surfaces, wherein at least one of said surfaces is coated with an antimicrobial treatment,

wherein said antimicrobial treatment comprises a silane quaternary ammonium salt,

wherein said antimicrobial treatment comprises an antimicrobial treatment solution comprising said silane quaternary ammonium salt and isopropyl alcohol,

wherein the antimicrobial treatment solution comprises about 30 percent to about 50 percent by volume of isopropyl alcohol,

wherein the antimicrobial treatment solution comprises about 50 percent to about 70 percent by volume of said silane quaternary ammonium salt,

wherein said silane quaternary ammonium salt includes an unreacted organofunctional silane to promote bonding to the surfaces of the component, and

wherein said silane quaternary ammonium salt comprises 0.1 to 5 percent by weight 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride.

2. The vascular access product of claim 1, wherein said antimicrobial treatment is substantially free from arsenic, silver, tin, heavy metals and polychlorinated phenols.

3. The vascular access product of claim 1, wherein the antimicrobial treatment is covalently bonded to the at least one of said surfaces and is capable of emitting ions that aid in the destruction of a microbe.

4. The vascular access product of claim 1, wherein said vascular access product is selected from the group consisting of a catheter and a PICC line.

5. A catheter comprising:

a component having a plurality of external surfaces, wherein at least one of said surfaces is coated with an antimicrobial treatment,

wherein said antimicrobial treatment comprises a silane quaternary ammonium salt,

wherein said antimicrobial treatment comprises an antimicrobial treatment solution comprising said silane quaternary ammonium salt and isopropyl alcohol,

wherein the antimicrobial treatment solution comprises about 30 percent to about 50 percent by volume of isopropyl alcohol,

wherein the antimicrobial treatment solution comprises about 50 percent to about 70 percent by volume of said silane quaternary ammonium salt,

wherein said silane quaternary ammonium salt includes an unreacted organofunctional silane to promote bonding to the surfaces of the component, and

wherein said silane quaternary ammonium salt comprises 0.1 to 5 percent by weight 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride.

6. The catheter of claim 5, wherein said catheter is selected from the group consisting of an acute hemo-dialysis catheter;

a chronic hemo-dialysis catheter; and

a peritoneal dialysis catheter.