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Modulation of hepatitis B virus (HBV) expression

  • US 9,677,076 B2
  • Filed: 07/07/2015
  • Issued: 06/13/2017
  • Est. Priority Date: 04/21/2011
  • Status: Active Grant
First Claim
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1. A single stranded modified oligonucleotide consisting of 20 to 30 linked nucleosides and having a nucleobase sequence comprising any of the nucleobase sequences of SEQ ID NOs:

  • 321-331, 333, 352-362, 365-375, 378, 379, 433, 491-497, 511-513, 515, 605-629, 632-634, 650-666, 700-708, 742-746, 770, 771, 774-777, 811, 918,919, 924-926, 928, 947, 948, 950-956, 971, 972, 974-982, 995, 997-1004, 1055-1063, 1067-1105, 1119-1132, 1145, 1147-1161, 1180-1185, 1188-1205, 1207-1223, 1236-1241, 1255-1258, 1271, or 1272, wherein the modified oligonucleotide comprises;

    a gap segment consisting of linked deoxynucleosides;

    a 5′

    wing segment consisting of linked nucleosides; and

    a 3′

    wing segment consisting of linked nucleosides;

    wherein the gap segment is positioned between the 5′

    wing segment and the 3′

    wing segment and wherein each nucleoside of each wing segment comprises a modified sugar.

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