Diagnostic method and breath testing device
First Claim
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1. A method of diagnosing celiac disease in a subject comprising:
- providing a hand-held breath detector comprising a mouthpiece, a trap and a hydrogen selective sensor which operates at room temperature and detects a hydrogen concentration at levels as low as 10 ppm in a breath sample;
using the hand-held breath detector on a subject to detect a hydrogen concentration in a fasting breath sample of the subject, wherein the fasting breath sample of the subject is taken without requiring the subject to ingest a xylose or sorbitol carbohydrate substrate within one hour to four hours of the breath test; and
diagnosing celiac disease in the subject if the hydrogen concentration in the fasting breath sample is above a threshold concentration.
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Abstract
The present invention relates to a diagnostic method and breath-testing device for the diagnosis of Celiac Disease or other gastrointestinal malabsorption in adults and children, and uses a hydrogen selective sensor in the form of a ZnO nanowire-based sensor fabricated using a focused ion beam (FIB/SEM) instrument or a thin film.
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Citations
9 Claims
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1. A method of diagnosing celiac disease in a subject comprising:
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providing a hand-held breath detector comprising a mouthpiece, a trap and a hydrogen selective sensor which operates at room temperature and detects a hydrogen concentration at levels as low as 10 ppm in a breath sample; using the hand-held breath detector on a subject to detect a hydrogen concentration in a fasting breath sample of the subject, wherein the fasting breath sample of the subject is taken without requiring the subject to ingest a xylose or sorbitol carbohydrate substrate within one hour to four hours of the breath test; and diagnosing celiac disease in the subject if the hydrogen concentration in the fasting breath sample is above a threshold concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification