Low-cost point-of-care assay device
First Claim
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1. A micro-fluidic device configured to perform an assay of a liquid sample, the device comprising:
- a sample application site in communication with a capillary channel;
a vent outlet in communication with the capillary channel; and
a capping element configured to seal both the vent outlet and the sample application site from an outside environment, wherein the capping element is configured to provide a sealed volume over the sample application site and the vent outlet separate from the outside environment and is configured to provide a sealed volume of a gas shared between the sample application site and the vent outlet.
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Abstract
The present disclosure provides methods and systems for analyzing a liquid sample. A micro-fluidic device to perform an assay of a liquid sample is described that includes a sample application site and a vent outlet in fluid communication with the capillary channel. A cap is provided that is configured to seal both the vent outlet and the sample application site in a shared volume and separate from an outside environment.
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Citations
22 Claims
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1. A micro-fluidic device configured to perform an assay of a liquid sample, the device comprising:
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a sample application site in communication with a capillary channel; a vent outlet in communication with the capillary channel; and a capping element configured to seal both the vent outlet and the sample application site from an outside environment, wherein the capping element is configured to provide a sealed volume over the sample application site and the vent outlet separate from the outside environment and is configured to provide a sealed volume of a gas shared between the sample application site and the vent outlet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 18, 19, 20, 21, 22)
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8. A method for performing an assay of a liquid sample, the method comprising:
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applying a liquid sample to a sample application site in fluid communication with a capillary channel wherein the liquid sample flows via a capillary action force through the capillary channel; providing venting for the capillary action force through a vent outlet; and sealing the liquid sample from the outside environment with a capping element, wherein the capping element provides a shared sealed volume around both the sample application site and the vent outlet. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A system comprising:
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(a) a reader; and (b) a micro-fluidic device configured to perform an assay of a liquid sample and loaded into the reader, the device comprising; a sample application site in communication with a capillary channel; a vent outlet in communication with the capillary channel; and a capping element configured to seal both the vent outlet and the sample application site from an outside environment, wherein the capping element is configured to provide a sealed volume over the sample application site and the vent outlet separate from the outside environment and is configured to provide a sealed volume of a gas shared between the sample application site and the vent outlet. - View Dependent Claims (17)
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Specification