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System and method of modeling erythropoiesis including iron homeostasis

  • US 9,679,111 B2
  • Filed: 11/05/2013
  • Issued: 06/13/2017
  • Est. Priority Date: 11/05/2012
  • Status: Active Grant
First Claim
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1. A hemodialysis system comprising:

  • a hemodialysis machine comprisinga blood pump;

    a modular drug delivery device comprising at least one erythropoiesis stimulating agent (ESA) pump, at least one iron replacement product pump, at least one ESA vial holder, and at least one iron replacement product vial holder; and

    a housing to which the blood pump and the modular drug delivery device are secured;

    a blood line set comprising multiple blood lines and a drip chamber in fluid communication with the multiple blood lines, at least one of the blood lines being connected to the drip chamber, the blood line set being connected to the blood pump in a manner such that, when the blood line set is connected to a patient and the blood pump is operated, blood of the patient is passed through the blood line set;

    a drug administration fluid line set comprising multiple drug lines, at least two of the drug lines of the drug line set being connected to the drip chamber of the blood line set, and the drug line set being connected to the at least one ESA pump and the at least one iron replacement product pump in a manner such that, when the drug line set is fluidly connected to an ESA vial contained in the at least one ESA vial holder and to an iron replacement product vial contained in the at least one iron replacement product vial holder, and the at least one ESA pump and the at least one replacement product pump are operated, ESA and iron replacement product are delivered from the ESA vial and the iron replacement vial, respectively, to the drip chamber of the blood line set via the drug line set; and

    a control unit comprising a mathematical model of erythropoiesis and iron metabolism and instructions that, when executed, cause the control unit to adjust the patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time by i) employing the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at a predetermined time, the model including iron homeostasis, and by ii) operating the blood pump, the at least one ESA pump, and the at least one iron replacement product pump to deliver blood, ESA, and iron replacement product to the drip chamber via the at least one of the blood lines connected to the drip chamber and the at least two of the drug lines connected to the drip chamber, according to an ESA administration regimen predicted to adjust the patient'"'"'s hematocrit and/or hemoglobin concentration to a value within the desired range at the predetermined time,wherein the mathematical model of erythropoiesis and iron metabolism comprises the functions;

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