Integrated catalytic protection of oxidation sensitive materials
First Claim
1. A sensor having an in vivo functionality, the sensor comprising:
- a sensor body encasing a photosensitive detector element and a light source, the sensor body comprising an exterior surface and a groove in the exterior surface;
a porous sensor graft on at least the groove in the exterior surface of the sensor body, wherein the porous graft comprises one or more indicator macromolecules; and
a protective material in close proximity to the porous sensor graft and surrounding one or more of (i) a portion or all of the porous sensor graft and (ii) a portion of the exterior surface of the sensor body, wherein;
(1) the protective material prevents or reduces degradation or interference of the porous sensor graft due to inflammation reactions and/or foreign body response;
(2) the protective material comprises a metal or metal oxide which catalytically decomposes or inactivates in vivo reactive oxygen species or biological oxidizers; and
(3) the protective material does not completely surround the sensor body.
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Accused Products
Abstract
An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
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Citations
57 Claims
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1. A sensor having an in vivo functionality, the sensor comprising:
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a sensor body encasing a photosensitive detector element and a light source, the sensor body comprising an exterior surface and a groove in the exterior surface; a porous sensor graft on at least the groove in the exterior surface of the sensor body, wherein the porous graft comprises one or more indicator macromolecules; and a protective material in close proximity to the porous sensor graft and surrounding one or more of (i) a portion or all of the porous sensor graft and (ii) a portion of the exterior surface of the sensor body, wherein; (1) the protective material prevents or reduces degradation or interference of the porous sensor graft due to inflammation reactions and/or foreign body response; (2) the protective material comprises a metal or metal oxide which catalytically decomposes or inactivates in vivo reactive oxygen species or biological oxidizers; and (3) the protective material does not completely surround the sensor body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 49, 50, 51, 52)
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8. A sensor having an in vivo functionality, the sensor comprising:
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a sensor body encasing a photosensitive detector element and a light source, the sensor body comprising an exterior surface and having a saddle-cut shape in the exterior surface; a porous sensor graft on at least a portion of the exterior surface of the sensor body, wherein the porous graft comprises one or more indicator macromolecules; and a layer of protective coating applied onto one or more of (i) a portion or all of the porous sensor graft and (ii) a portion of the exterior surface of the sensor body, wherein; (1) the protective coating prevents or reduces degradation or interference of the porous sensor graft from inflammation reactions and/or foreign body response; (2) the protective coating comprises a metal or metal oxide which catalytically decomposes or inactivates in vivo reactive oxygen species or biological oxidizers; and (3) the layer of protective coating does not completely surround the sensor body. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for using a sensor for in vivo applications comprising:
implanting a sensor in a subject body, wherein the sensor has an in vivo functionality and comprises a sensor body encasing a photosensitive detector element and a light source, comprising an exterior surface, and having a saddle-cut shape in the exterior surface;
a porous sensor graft on at least a portion of the exterior surface of the sensor body, the porous graft comprising one or more indicator macromolecules; and
a layer of a protective coating on one or more of (i) a portion or all of the porous sensor graft and (ii) a portion of the exterior surface of the sensor body, wherein;(1) the protective coating prevents or reduces degradation or interference of the porous sensor graft due to inflammation reactions and/or foreign body response; (2) the protective coating comprises a metal or metal oxide which catalytically decomposes or inactivates in vivo reactive oxygen species or biological oxidizers; and (3) the protective coating does not completely surround the sensor body. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for detecting the presence or concentration of an analyte in an in vivo sample, said method comprising:
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(a) exposing the sample to a porous sensor graft of a sensor, the porous sensor graft having a detectable quality that changes when the porous sensor graft is exposed to the analyte, said sensor comprising a sensor body encasing a photosensitive detector element and a light source, comprising an exterior surface, and having a saddle-cut shape in the exterior surface;
a porous sensor graft on at least a portion of the exterior surface of the sensor body, the porous graft comprising one or more indicator macromolecules; and
a layer of protective coating applied onto one or more of (i) a portion or all of the porous sensor graft and (ii) a portion of the exterior surface of the sensor body, wherein;(1) the protective coating prevents or reduces degradation or interference of the porous sensor graft from inflammation reactions and/or foreign body response; (2) the protective coating comprises a metal or metal oxide which catalytically decomposes or inactivates in vivo reactive oxygen species or biological oxidizers; and (3) the protective coating does not completely surround the sensor body, such that the sensor has enhanced resistance to degradation or interference as compared to a corresponding sensor without the protective coating; and (b) measuring any change in said detectable quality to thereby determine the presence or concentration of said analyte in said sample. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. An implantable glucose sensor for determining the presence or concentration of glucose in an animal, said sensor comprising:
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(a) a sensor body having an outer surface surrounding said sensor body and a groove in the outer surface; (b) a radiation source in said sensor body which emits radiation within said sensor body; (c) an indicator element that is affected by the presence or concentration of glucose in said animal, said indicator element being on at least the groove in said outer surface of said sensor body; (d) a photosensitive element located in said sensor body and positioned to receive radiation within the sensor body, said photosensitive element configured to generate a signal responsive to radiation received from said indicator element and which is indicative of the presence or concentration of glucose in said animal; and (e) a protective barrier comprising silver, palladium, platinum, manganese, or alloys, or gold-inclusive alloys, or combinations thereof, surrounding one or more of (i) a portion or all of said indicator element and (ii) a portion of said outer surface of said sensor body, wherein the protective barrier surrounds one or more of (1) a portion or all of said indicator element and (2) a portion of said outer surface of said sensor body, and the protective barrier does not completely surround the sensor body. - View Dependent Claims (46, 47, 48, 53, 54, 55, 56, 57)
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Specification