Oral care product and methods of use and manufacture thereof

• US 9,682,026 B2
• Filed: 03/28/2008
• Issued: 06/20/2017
• Est. Priority Date: 02/08/2008
• Status: Active Grant

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Prencipe, Michael, Leite, Sergio, Simon, Eric A., Santarpia, III, Ralph Peter, Morgan, Andre M., Cummins, Diane, Robinson, Richard Scott, Sullivan, Richard J., Subramanyam, Ravi, Mello, Sarita V., Kohli, Rajnish, Wang, Qin, Tambs, Gary Edward, Barnes, Virginia Monsul, Zaidel, Lynette, Wu, Donghui, Chopra, Suman
• Primary Examiner(s): Roberts, Lezah
• Application Number:
  US12/058,360
• Publication Number:
  US 20090202455A1
• Time in Patent Office: 3,371 Days
• Field of Search: 424 52, 424 54, 424682, 424687
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to oral care compositions comprising an effective amount of a salt of a basic amino acid the salt having a pH in an unbuffered solution of less than about 7.5; an effective amount of a soluble fluoride salt; and a particulate material which has a pH in an unbuffered solution of less than about 7.5; and to methods of using and of making such compositions.

Claims

1. An oral care composition comprising

a. an effective amount of arginine phosphate;

b. an effective amount of sodium monofluorophosphate;

c. a particulate material which has a pH in an unbuffered solution of less than about 7.5,

wherein the particular material comprises dicalcium phosphate dihydrate;

wherein the composition has a pH between 6.8 and 7.2; and

wherein the composition is substantially free of organic phosphates.

2. A composition of claim 1 which is a dentifrice.

3. A composition of claim 1 further comprising an anionic surfactant.

4. A composition according to claim 3 wherein the anionic surfactant is sodium lauryl sulfate.

5. A composition of claim 1 further comprising an antibacterial agent.

6. A composition according to claim 5 wherein the antibacterial agent is zinc citrate.

7. A composition of claim 1 further comprising an anionic polymer.

8. A composition according to claim 7 wherein the anionic polymer is a copolymer of methyl vinyl ether and maleic anhydride.

9. A composition according to claim 1, wherein a radioactive dentin abrasion (RDA) of the composition is less than 150.

10. A composition according to claim 1 in the form of a toothpaste further comprising one or more of water, abrasives surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, antimicrobial agents, preservatives, flavorings, colorings and/or combinations thereof.

11. A method comprising applying an effective amount of the oral composition of claim 1 to an oral cavity to a. reduce or inhibit formation of dental caries, b. reduce, repair or inhibit early enamel lesions, c. reduce or inhibit demineralization and promote remineralization of the teeth, d. reduce hypersensitivity of the teeth, e. reduce or inhibit gingivitis, f. promote healing of sores or cuts in the mouth, g. reduce levels of acid producing bacteria, h. increase relative levels of arginolytic bacteria, i. inhibit microbial biofilm formation in the oral cavity, j. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, k. reduce plaque accumulation, l. treat, relieve or reduce dry mouth, m. immunize the teeth against cariogenic bacteria, n. whiten teeth, o. reduce erosion, p. clean the teeth and oral cavity, and/or q. promote systemic health, including cardiovascular health.

12. The method of claim 11, wherein the applying is to reduce or inhibit formation of dental caries.

13. An oral care composition according to claim 1 wherein the arginine phosphate is present in an amount to provide from 0.1 to 20 wt % of arginine free base by weight of the total composition.

14. An oral care composition according to claim 1 wherein the arginine phosphate is present in an amount to provide from 1 to 15 wt % of arginine free base by weight of the total composition.

15. An oral care composition according to claim 1 wherein the soluble fluoride salt is present in an amount of from 0.01 to 2 wt % of the total composition weight.

16. An oral care composition according to claim 1 wherein the sodium monofluorophosphate is present in an amount to provide 50 to 25,000 ppm by weight of fluoride ions in the total composition weight.

17. An oral care composition according to claim 1 wherein the dicalcium phosphate dihydrate is present in an amount of from 15-70 wt % of the total composition weight.

18. A composition according to claim 6, wherein the zinc citrate is present in an amount of 0.01 to 5% by weight of the total composition.