×

Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current

  • US 9,682,041 B2
  • Filed: 05/02/2014
  • Issued: 06/20/2017
  • Est. Priority Date: 06/03/2011
  • Status: Active Grant
First Claim
Patent Images

1. A composition for treating or preventing drug induced QT prolongation in a human or animal subject comprising:

  • a combination of i) one or more pharmacologically active agents that induce QT prolongation in the subject; and

    ii)one or more empty liposomes, wherein the empty liposomes are provided in an amount sufficient to prevent or reduce the QT prolongation caused by the one or more pharmacologically active agents, wherein the combination is dispersed in a pharmaceutically acceptable medium, solvent, or vehicle and wherein said combination of i) and ii) reduces hERG current inhibition as compared to i) alone.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×