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Compositions and methods for modulating metabolic pathways

  • US 9,682,053 B2
  • Filed: 05/25/2016
  • Issued: 06/20/2017
  • Est. Priority Date: 07/15/2011
  • Status: Active Grant
First Claim
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1. A composition comprising:

  • (a) at least 500 mg of leucine and/or at least 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and

    (b) at least 1 mg of a sirtuin pathway activator that is an anti-diabetic agent selected from the group consisting of a dipeptidyl peptidase (DPP) inhibitor, incretin and/or incretin mimetic;

    wherein the composition is substantially free of the individual amino acids alanine, glutamic acid, glycine, isoleucine, valine, and proline;

    wherein the composition is formulated as a tablet, capsule, gel capsule, beverage, snack bar or a food composition;

    wherein when (a) is a metabolite of leuine the molar ratio of (a) to (b) is greater than 10; and

    wherein when (a) is leucine, the molar ratio of (a) to (b) is greater than 500.

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