Methods and systems for dosing control in an automated fluid delivery system

• US 9,682,192 B2
• Filed: 06/27/2016
• Issued: 06/20/2017
• Est. Priority Date: 03/04/2013
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Marsh, Charles, McCutchan, Larry
• Primary Examiner(s): LONG, DONNELL ALAN
• Application Number:
  US15/193,915
• Publication Number:
  US 20160303320A1
• Time in Patent Office: 358 Days
• Field of Search: 600 4, 222 63
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14228 with linear peristaltic action, i.e. comprising at least three pressurising members or a helical member
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: F04B 43/02 having plate-like flexible members, e.g. diaphragms F04B43/14 takes precedence
• CPC Class Codes: F04B 43/12 having peristaltic action
• CPC Class Codes: F04B 43/14 having plate-like flexible members
• CPC Class Codes: F04B 49/065 and making use of computers
• CPC Class Codes: F04B 49/106 Responsive to pumped volume

Abstract

Methods and systems for dispensing a fluid using an automated fluid delivery system are disclosed. A pump may be configured to force an aliquot of fluid into a fluid delivery channel. A processor may receive values of a property for the aliquot and the source of the aliquot. The processor may use the values to determine the volume of the aliquot. The determined volume is compared by the processor against an expected volume to establish the amount of fluid being pumped by the pump per unit, such as time or revolutions. The processor controls operation of the pump to dispense a predetermined dose based on the amount of fluid being pumped by the pump per unit.

Claims

1. A system for dispensing a fluid, comprising:

a syringe pump configured to force an aliquot of a medical fluid from a fluid source into a fluid delivery channel;

at least one optical sensor configured to measure a sample value of a property of the aliquot, wherein the property is selected from the group consisting of concentration, salinity, optical properties, analyte concentration and combinations thereof;

a processor in communication with the syringe pump and the at least one optical sensor; and

a non-transitory, computer-readable storage medium in operable communication with the processor, wherein the computer-readable storage medium contains one or more programming instructions that, when executed, cause the processor to;

receive the sample value of the property of the aliquot,

receive a source value of the property for the fluid source,

determine a sample volume of the aliquot based on a comparison of the sample value and the source value,

determine a pump coefficient based on a comparison of the sample volume with an expected volume, wherein the pump coefficient is configured to indicate a volume of the medical fluid forced into the fluid delivery channel per unit, and

control operation of the syringe pump to dispense a predetermined dose of the medical fluid based on the comparison of the sample volume with the expected volume.

2. The system of claim 1, wherein the property comprises an optical property.

3. The system of claim 1, wherein the property comprises an analyte concentration.

4. The system of claim 1, wherein the pump coefficient comprises a volume-per-time coefficient.

5. The system of claim 1, wherein the pump coefficient comprises a volume-per-linear travel distance coefficient.

6. The system of claim 1, wherein the one or more programming instructions, that, when executed, cause the processor to control operation of the syringe pump further comprise one or more programming instructions that, when executed, cause the processor to control operation of the syringe pump using the pump coefficient.

7. The system of claim 1, wherein the one or more programming instructions that, when executed, cause the processor to control operation of the syringe pump further comprise one or more programming instructions that, when executed, cause the processor to adjust the pump coefficient to correspond with dispensing the predetermined dose.

8. The system of claim 1, wherein the sample volume of the aliquot is affected by at least one dimensional property of the fluid delivery channel.

9. The system of claim 8, wherein the at least one dimensional property of the fluid delivery channel at a first section of the fluid delivery channel is different from the at least one dimensional property at a second section of the fluid delivery channel.

10. The system of claim 9, wherein the first section of the fluid delivery channel is made of a first material and the second section of the fluid delivery channel is made of a second material.

11. The system of claim 10, wherein a difference between at least one dimensional property of the first section and the second section of the fluid delivery channel is determined by different characteristics of the first material and the second material.

12. The system of claim 8, wherein the at least one dimensional property of the fluid delivery channel is selected from the group consisting of an inner diameter of the fluid delivery channel, an outer diameter of the fluid delivery channel, a thickness of a wall of the fluid delivery channel, and combinations thereof.

13. The system of claim 8, wherein the at least one dimensional property varies along a length of the fluid delivery channel.

14. The system of claim 1, wherein the processor adjusts the control of the syringe pump to provide a consistent volume delivered regardless of a dimensional property of the fluid delivery channel.

15. The system of claim 1, wherein the expected volume comprises a volume of the medical fluid forced by the syringe pump under standard conditions.

16. The system of claim 1, wherein the non-transitory, computer- readable storage medium comprises a remote operated touch screen.

17. A method of dispensing a medical fluid, comprising:

providing a syringe pump configured to force an aliquot of a medical fluid from a fluid source into a fluid delivery channel;

receiving, by a processor, a source value of an optical property for the fluid source and a sample value of the optical property for the aliquot measured by at least one optical sensor;

determining, by the processor, a sample volume of the aliquot based on a comparison of the sample value of the optical property and the source value of the optical property;

determining, by the processor, a pump coefficient based on a comparison of the sample volume with an expected volume, wherein the pump coefficient is configured to indicate a volume of the medical fluid forced into the fluid delivery channel per linear distance traveled; and

controlling, by the processor, operation of the syringe pump to dispense a predetermined dose of the medical fluid based on a comparison of the sample volume with the expected volume.

18. The method of claim 17, wherein the pump coefficient comprises a volume-per-time coefficient.

19. The method of claim 17, wherein the pump coefficient comprises a volume-per-linear travel distance coefficient.

20. The method of claim 17, wherein controlling operation of the syringe pump further comprises controlling the syringe pump using the pump coefficient.