Deep brain magnetic stimulator

• US 9,682,248 B2
• Filed: 09/19/2013
• Issued: 06/20/2017
• Est. Priority Date: 09/20/2012
• Status: Active Grant

• Current Assignee: University of Rochester
• Original Assignee: University of Rochester
• Inventors: Huang, Jason Haitao, Dayawansa, Samantha
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): Dorna, Carrie R
• Application Number:
  US14/031,404
• Publication Number:
  US 20140081072A1
• Time in Patent Office: 1,370 Days
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

A deep brain magnetic stimulator is disclosed that is placed within a vessel of the body to provide targeted location specific application of a magnetic field within the brain. The deep brain magnetic stimulator has a stimulation coil affixed to an expandable device core where the device core has a lumen to allow the passage of blood. A source of electrical energy is provided as well as related control circuitry to govern the activation of the stimulation coil and also govern such parameters as magnetic field strength, duration, waveform, and the like.

Claims

1. A deep brain magnetic stimulator comprising:

a device core capable of being placed in a luminal periphery of a blood vessel where the device core is generally tubular in shape and comprises a lumen to allow the unassisted passage of blood and a lumen wall having expandable elements;

a stimulation coil affixed to the device core comprising a conductive element, wherein the stimulation coil is disposed around the entire outer circumference of the device core;

the stimulation coil configured to generate a non-revolving magnetic field;

an energy storage device electrically coupled to the stimulation coil to deliver voltage and current to the stimulation coil without resonance of the stimulation coil with the energy storage device; and

control circuitry comprising a power handling module to control the delivery of voltage and current to the stimulation coil, and a control module to control activation of the stimulation coil.

2. The deep brain magnetic stimulator of claim 1, wherein the expandable elements are stent scaffolding elements.

3. The deep brain magnetic stimulator of claim 1, wherein the expandable elements are expandable folds.

4. The deep brain magnetic stimulator of claim 3, wherein the expandable folds of the device core are generally parallel to the longitudinal axis of the device core and when folded create a device core of a lesser diameter than the diameter of the device core when the folds are expanded.

5. The deep brain magnetic stimulator of claim 1, wherein the outer diameter of the device core is from about 1 French to about 15 French.

6. The deep brain magnetic stimulator of claim 1, wherein the overall length of the device core is from about 4 millimeters to about 30 millimeters.

7. The deep brain magnetic stimulator of claim 1, wherein the device core is selected from the group consisting of stainless steel, tantalum, cobalt chromium, nitinol, and shape memory polymers.

8. The deep brain magnetic stimulator claim 1, further comprising a silicon carbide coating on the device core.

9. The deep brain magnetic stimulator of claim 1, further comprising a drug-eluting coating on the device core.

10. The deep brain magnetic stimulator of claim 9, wherein the drug-eluting coating is selected from the group consisting of heparin, paclitaxel, and sirolimus.

11. The deep brain magnetic stimulator of claim 1, wherein the stimulation coil is made from a conductive element selected from the group consisting of copper, iron, silver and gold.

12. The deep brain magnetic stimulator of claim 1, further comprising a biocompatible coating on the stimulation coil.

13. The deep brain magnetic stimulator of claim 1, further comprising a ferromagnetic core where the conductive element of the stimulation coil is wound around said ferromagnetic core.

14. The deep brain magnetic stimulator of claim 1, further comprising a magnetic core where the conductive element of the stimulation coil is wound around said magnetic core.

15. The deep brain magnetic stimulator of claim 1, wherein the energy storage device is a capacitor.

16. The deep brain magnetic stimulator of claim 1, further comprising a charging coil in electrical communication with the energy storage device.

17. A system for deep brain magnetic stimulation comprising:

the deep brain magnetic stimulator of claim 1;

a physician control and telemetry device in wireless communication with the control module of the deep brain magnetic stimulator; and

a data storage device for retaining operational data of the deep brain magnetic stimulator.

18. The system for deep brain magnetic stimulation of claim 17, further comprising a patient control device in wireless communication with the deep brain magnetic stimulator.

19. A deep brain magnetic stimulator comprising:

a device core capable of being placed in a luminal periphery of a blood vessel where the device core is generally tubular in shape and comprises a lumen to allow the unassisted passage of blood and a lumen wall having expandable element, wherein the stimulation coil is disposed around the entire outer circumference of the device core;

a stimulation coil affixed to the device core comprising a conductive element;

the stimulation coil configured to generate a non-revolving magnetic field;

a battery electrically coupled to the stimulation coil; and

control circuitry comprising a power handling module to control the delivery of voltage and current to the stimulation coil, and a control module to control activation of the stimulation coil.

20. A method for developing improved treatment protocols for deep brain magnetic stimulation comprising the steps of:

receiving on a computer magnetic stimulation event information from

a deep brain magnetic stimulator comprising;

a device core capable of being placed in a luminal periphery of a blood vessel where the device core is generally tubular in shape and comprises a lumen to allow the unassisted passage of blood and a lumen wall having expandable elements;

a stimulation coil affixed to the device core comprising a conductive element;

the stimulation coil configured to generate a non-revolving magnetic field;

an energy storage device electrically coupled to the stimulation coil; and

control circuitry comprising a power handling module to control delivery of voltage and current to the stimulation coil, and a control module to control activation of the stimulation coil;

the information comprising magnitude of magnetic stimulation, duration of magnetic stimulation, and date and time of magnetic stimulation;

receiving on the computer body function information from a patient comprising body function metrics that correlate to the date and time of a magnetic stimulation event;

correlating on the computer a unique patient identifier to the magnetic stimulation event information and the body function information;

correlating on the computer the magnetic stimulation event information and the body function information by patient identifier and date and time; and

identifying on the computer trends between patients to develop improved treatment protocols.