Integrated radiation therapy systems and methods for treating a target in a patient

• US 9,682,253 B2
• Filed: 07/25/2005
• Issued: 06/20/2017
• Est. Priority Date: 06/05/2002
• Status: Active Grant

• Current Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Original Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Inventors: Meier, Eric, Mate, Timothy P., Wright, J. Nelson, Dimmer, Steven C., Purdy, Lynn M.
• Primary Examiner(s): Le, Long V
• Assistant Examiner(s): Weatherby, Ellsworth
• Application Number:
  US11/190,193
• Publication Number:
  US 20060074301A1
• Time in Patent Office: 4,348 Days
• Field of Search: 600427, 600424
• CPC Class Codes: A61N 2005/1051 using an active marker markers in general A61B90/39
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

Claims

1. A method for assessing a treatment fraction in radiation therapy, the method comprising;

irradiating a patient with a radiation beam according to desired radiation dosage levels associated with a predetermined treatment plan;

while irradiating the patient, producing target data indicative of at least one of size and shape of a target within the patient without acquiring images of the target within the patient, wherein producing the target data includes—

periodically locating one or more of a plurality of markers positioned within the patient relative to an external reference frame using a localization modality, and

determining the relative distances between the periodically located markers within the patient;

using the target data to produce an assessment of radiation dosage levels to which the patient was exposed while irradiated; and

producing an adapted treatment plan based on differences between the desired radiation dosage levels and the assessment of radiation dosage levels.

2. The method of claim 1 wherein:

each of the markers comprises a magnetic transponder;

periodically locating the markers includes using a non-ionizing energy to locate each of the markers while irradiating the patient, wherein the non-ionizing energy comprises a wirelessly transmitted magnetic field alternating at a resonant frequency of a corresponding one of the markers; and

the method further comprises

wirelessly transmitting corresponding location signals from each of the markers,

sensing the location signals from each of the markers with a sensor array external to the patient, and

calculating three-dimensional location coordinates of each of the markers in the external reference frame.

3. The method of claim 1 wherein using the target data to produce an assessment of radiation dosage levels comprises

while irradiating the patient, acquiring hardware data of a radiation delivery device related to at least one of position of a table supporting the patient, position of a gantry, configuration of a collimator, shape of the radiation beam, gate of the radiation beam, contour of the radiation beam, angle of the radiation beam, intensity of the radiation beam, pulse width of the radiation beam, isocenter of the radiation beam, and position of the radiation beam;

and

correlating the target data with the hardware data.

4. The method of claim 3 wherein the correlating includes correlating the target data with the hardware data while irradiating the patient.

5. A method for assessing a treatment fraction in radiation therapy, the method comprising:

irradiating a patient located in a radiation vault with a radiation beam according to desired radiation dosage levels associated with a predetermined treatment plan;

producing target data indicative of at least one of size and shape of a target within the patient without acquiring images of the target within the patient while irradiating the patient, wherein producing the target data includes

periodically locating one or more of a plurality of markers positioned within the patient relative to an external reference frame using a localization modality, and

determining the relative distances between the periodically located markers within the patient;

producing hardware data by periodically locating a hardware marker attached to a device in the radiation vault without acquiring images of the target within the patient while irradiating the patient;

using the target data and the hardware data to produce an assessment of radiation dosage levels to which the patient was exposed while irradiated; and

producing an adapted treatment based on differences between the desired radiation dosage levels and the assessment of radiation dosage levels.

6. The method of claim 5 wherein:

each of the markers comprises a magnetic transponder;

periodically locating the markers includes using a non-ionizing energy to locate the markers while irradiating the patient, wherein the non-ionizing energy comprises a wirelessly transmitted magnetic field alter alternating at a resonant frequency of a corresponding one of the markers; and

the method further comprises

wirelessly transmitting corresponding locations signals from the markers,

sensing the location signals from the markers with a sensor array external to the patient, and

calculating three-dimensional location coordinates of the markers in the external reference frame.

7. The method of claim 5 wherein using the target data to produce an assessment of radiation dosage levels comprises

while irradiating the patient, acquiring hardware data of a radiation delivery device related to at least one of position of a table supporting the patient, position of a gantry, configuration of a collimator, shape of the radiation beam, gate of the radiation beam, contour of the radiation beam, angle of the radiation beam, intensity of the radiation beam, pulse width of the radiation beam, isocenter of the radiation beam, and position of the radiation beam;

and

correlating the target data with the hardware data.

8. The method of claim 7 the correlating includes correlating the target data with the hardware data while irradiating the patient.

9. A method of assessing performance of a treatment fraction in radiation therapy, comprising:

irradiating a target within a patient with a radiation beam of a radiation delivery device according to desired radiation dosage levels associated with a predetermined treatment plan;

while irradiating the target and without acquiring computerized tomography images of the target within the patient

periodically locating one or more of a plurality of markers positioned within the patient proximate the target and relative to a reference frame using a localization system that monitors the markers and outputs objective target data over a substantially continuous period of time, wherein the target data includes relative distances between the periodically located markers within the patient and indicates at least one of size and shape of the target within the patient, and

recording hardware data of the radiation delivery device while irradiating the patient;

correlating the target data with the hardware data to produce an assessment of radiation dosage levels to which the patient was exposed while irradiated; and

producing an adapted treatment plan based on differences between the desired radiation dosage levels and the assessment of radiation dosage levels.