Cancer surface searing apparatus and method of use thereof

• US 9,682,254 B2
• Filed: 03/17/2014
• Issued: 06/20/2017
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Pavel Balakin, Vladimir Balakin
• Inventors: Balakin, Pavel, Balakin, Vladimir
• Primary Examiner(s): NGUYEN, KIET TUAN
• Application Number:
  US14/216,788
• Publication Number:
  US 20150258350A1
• Time in Patent Office: 1,191 Days
• Field of Search: 2504923
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 5/04 with beam-forming means
• CPC Class Codes: H01J 2237/0815 Methods of ionisation
• CPC Class Codes: H01J 37/141 Electromagnetic lenses
• CPC Class Codes: H05H 2007/007 for focusing the beam to irradiation target

Abstract

The invention comprises a charged particle cancer therapy system used to seal a periphery of a tumor, such as through use of a proton or carbon ion beam searing the outer edges of the tumor, which prevents/hinders nutrient delivery to the tumor resultant in stunted growth of the tumor, halted growth of the tumor, and/or starvation/necrosis of the tumor. Optionally, a tumor sealing layer is formed using multiple passes, of a treatment beam of the charged particle cancer therapy system, across a tumor/healthy tissue boundary layer or voxel.

Claims

1. A method for treating a tumor, within healthy tissue of a patient, with positively charged particles, the tumor comprising a tumor surface area and a tumor central volume, the method comprising the steps of:

accelerating the positively charged particles with a synchrotron to a first energy level;

rotating the patient on a rotational platform;

using a controller linked to said synchrotron and said rotational platform to target the tumor surface area with the positively charged particles, wherein said surface area of the tumor comprises at least one of;

an outer perimeter of the tumor;

portions of healthy tissue contacting the tumor; and

healthy tissue proximate the tumor; and

under control of said controller, delivering a therapeutic dosage of the positively charged particles to the tumor surface area of the tumor and a sub-therapeutic dosage of the charged particles to the central volume of the tumor.

2. The method of claim 1, further comprising the step of:

sealing the tumor surface area with a first sealing layer, the first sealing layer resisting nutrient flow to the tumor and resisting waste removal from the tumor, the first sealing layer formed through said step of delivering the therapeutic dosage of the positively charged particles to the tumor surface area of the tumor.

3. The method of claim 2, further comprising the step of:

forming a reinforcement sealing layer by treatment of voxels with the positively charged particles, said voxels comprising at least one of;

voxels overlapping the first sealing layer; and

voxels contacting the first sealing layer.

4. The method of claim 2, further comprising the step of:

said step of sealing indirectly treating the tumor by limiting oxygen flow to the tumor.

5. The method of claim 1, wherein said step of delivering further comprises the steps of:

delivering the charged particles to a subsection of the tumor surface area of the tumor along a first charged particle delivery axis;

delivering the charged particles to the subsection of the tumor along a second charged particle delivery axis, said first and said second charged particle delivery axes forming an angle of between 45 and 135 degrees, wherein said first charged particle delivery axis and said second charged particle delivery axis form an x/y-treatment plane.

6. The method of claim 5, wherein said step of delivering a therapeutic dosage further comprises the step of:

delivering the charged particles to the subsection of the tumor surface area of the tumor along a third charged particle delivery axis, said third charged particle delivery axis forming an angle between 45 and 135 degrees off of the x/y-treatment plane.

7. The method of claim 6, further comprising the step of:

repeating said step of delivering the therapeutic dosage to additional subsections of the tumor surface until greater than ninety-five percent of the tumor surface area is treated.

8. The method of claim 1, wherein said method of cancer therapy treats greater than fifty percent of the tumor with a sub-therapeutic dosage of the positively charged particles.

9. The method of claim 8, wherein said step of rotating further comprises the step of:

rotating the patient through multiple complete revolutions with treatment of the tumor in each full rotation of said multiple complete revolutions.

10. The method of claim 8, further comprising the step of:

repetitively scanning the positively charged particles along a radial tumor axis across the surface area of the tumor.

11. The method of claim 10, wherein the positively charged particles comprise C⁶⁺.

12. An apparatus for treating a tumor, within healthy tissue of a patient, with positively charged particles, the tumor comprising a tumor surface area and a tumor central volume, the apparatus comprising:

a synchrotron configured to accelerate the positively charged particles to a first energy level;

a rotational platform configured to hold and rotate the patient;

a controller linked to said synchrotron and said rotational platform, said controller configured to target the tumor surface area through rotation of the patient on the rotational platform and control of the positively charged particles from said synchrotron,

wherein said surface area of the tumor comprises at least one of;

an outer perimeter of the tumor;

portions of healthy tissue contacting the tumor; and

healthy tissue proximate the tumor; and

said controller configured to deliver a therapeutic dosage of the positively charged particles to the tumor surface area of the tumor and a sub-therapeutic dosage of the charged particles to a central volume of the tumor.

13. The apparatus of claim 12, further comprising:

a set of dynamic image data, delivered to an electronic storage medium, of information on location of the tumor in the patient, said controller configured to adjust said first energy level to selectively target a portion of the tumor surface area.

14. The apparatus of claim 13, further comprising:

a support configured to dynamically adjust the patient in a reclined position between five and forty-five degrees off of a horizontal axis, said controller configured to target different sections of the tumor surface area as a function of the reclined position.

15. The apparatus of claim 12, further comprising:

an extraction foil, said extraction foil configured in a beam path of the apparatus after said synchrotron and prior to a final Lambertson extraction magnet, said extraction foil comprising a thickness of twenty-five to two hundred twenty-five micrometers, said positively charged particles passing through said extraction foil during use.

16. The apparatus of claim 15, wherein said extraction foil further comprises:

a set of at least two foils, said controller configured to select which of said set of at least two foils to place in the charged particle beam path based on the first energy level.