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Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries

  • US 9,683,028 B2
  • Filed: 12/01/2014
  • Issued: 06/20/2017
  • Est. Priority Date: 04/17/2000
  • Status: Expired due to Term
First Claim
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1. A vector comprising:

  • (i) a DNA sequence encoding an antibody variable region linked to a fragment of a wild-type pIII anchor, which does not mediate infection of phage particles; and

    (ii) a wild-type gene III;

    wherein the nucleic acid sequence encoding the fragment of the wild-type pIII anchor in (i) differs from the portion of the wild-type gene III encoding the same fragment to an extent sufficient to reduce homologous recombination between the nucleic acid encoding the fragment of the wild-type PIII anchor in (i) and the wild-type gene III in (ii).

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