Agents for influenza neutralization
First Claim
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1. A composition comprising:
- an engineered antibody that binds to an epitope in the membrane proximal epitope region (MPER) of hemagglutinin (HA), which antibody comprises a heavy chain having an amino acid sequence that is at least 95% identical to SEQ ID NO;
1 and a light chain having an amino acid sequence that is at least 95% identical to one of SEQ ID NO;
33-43.
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Abstract
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.
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Citations
16 Claims
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1. A composition comprising:
- an engineered antibody that binds to an epitope in the membrane proximal epitope region (MPER) of hemagglutinin (HA), which antibody comprises a heavy chain having an amino acid sequence that is at least 95% identical to SEQ ID NO;
1 and a light chain having an amino acid sequence that is at least 95% identical to one of SEQ ID NO;
33-43. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- an engineered antibody that binds to an epitope in the membrane proximal epitope region (MPER) of hemagglutinin (HA), which antibody comprises a heavy chain having an amino acid sequence that is at least 95% identical to SEQ ID NO;
Specification