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Methods of reprogramming cells

  • US 9,683,215 B2
  • Filed: 08/24/2009
  • Issued: 06/20/2017
  • Est. Priority Date: 08/22/2008
  • Status: Active Grant
First Claim
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1. A method for reprogramming a first differentiated cell of exocrine origin to a second differentiated cell that exhibits at least two characteristics of a pancreatic β

  • -cell, does not express pancreatic hormones other than insulin and does not express amylase, the method comprising increasing protein expression of transcription factors Pdx-1, Ngn3 and MaFA in the first differentiated cell of exocrine origin, thereby reprogramming the first differentiated cell of exocrine origin to a second differentiated cell that exhibits at least two characteristics of a pancreatic β

    -cell, does not express pancreatic hormones other than insulin and does not express amylase, wherein the first differentiated cell of exocrine origin is isolated from a subject or located in vivo within the subject.

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